Drug Information

Drug General Information
Drug ID
D0L6TQ
Former ID
DIB020505
Drug Name
NCL-1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529968]
Structure
Download
2D MOL
Formula
C27H29N3O3
InChI
InChI=1S/C27H29N3O3/c28-24-17-23(24)21-12-7-13-22(16-21)33-15-14-25(30-26(31)20-10-5-2-6-11-20)27(32)29-18-19-8-3-1-4-9-19/h1-13,16,23-25H,14-15,17-18,28H2,(H,29,32)(H,30,31)/t23-,24+,25+/m0/s1
InChIKey
DTPSXFMGMQOVTG-ISJGIBHGSA-N
PubChem Compound ID
73755256
PubChem Substance ID
178103603
Target and Pathway
Target(s) Lysine specific histone demethylase 1 Target Info Inhibitor [531332]
Pathway Interaction Database Notch signaling pathway
Coregulation of Androgen receptor activity
Notch-mediated HES/HEY network
Reactome HDACs deacetylate histones
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Factors involved in megakaryocyte development and platelet production
WikiPathways Factors involved in megakaryocyte development and platelet production
Androgen receptor signaling pathway
References
Ref 529968Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res. 2009 Mar 1;69(5):2065-71.
Ref 531332Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor. Bioorg Med Chem. 2011 Jun 15;19(12):3702-8.

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