Drug General Information
Drug ID
D0L7UQ
Former ID
DAP001142
Drug Name
Prothionamide
Synonyms
Ektebin; Peteha; Prothionamidum; Protionamid; Protionamida; Protionamide; Protionamidum; Protionizina; Tebeform; Trevintix; Tuberex; RP 9778; TH 1321; Prothionamide (JP15); Protionamida [INN-Spanish]; Protionamide (INN); Protionamide [INN:DCF]; Protionamidum [INN-Latin]; TH-1321; Trevintix (TN); 2-Propyl-4-pyridinecarbothioamide; 2-Propyl-4-thiocarbamoylpyridine; 2-Propyl-thioisonicotinamide; 2-Propylisonicotinylthioamide; 2-Propylthioisonicotinamide; 2-propylpyridine-4-carbothioamide; 4-Pyridinecarbothioamide, 2-propyl-(9CI); 9778 R.P; 9778 R.P.
Drug Type
Small molecular drug
Indication Tuberculosis [ICD9: 010-018; ICD10:A15-A19] Approved [536338]
Therapeutic Class
Antituberculosis Agents
Structure
Download
2D MOL

3D MOL

Formula
C9H12N2S
Canonical SMILES
CCCC1=NC=CC(=C1)C(=S)N
InChI
1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
InChIKey
VRDIULHPQTYCLN-UHFFFAOYSA-N
CAS Number
CAS 14222-60-7
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
J04AD01
SuperDrug CAS ID
cas=014222607
Target and Pathway
Target(s) Enoyl-[acyl-carrier-protein] reductase [NADH] Target Info Inhibitor [536338], [537658]
References
Ref 536338Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16.
Ref 536338Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16.
Ref 537658Ability of the Ca2+ ionophores A23187 and ionomycin to mimic some of the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production, ornithine decarboxylase activity, and DNA synthesis in mouse epidermis in vivo. Cancer Res. 1990 Sep 15;50(18):5806-12.

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