TTD | Drug: D0L8HO

Drug General Information
Drug ID	D0L8HO
Former ID	DNC004406
Drug Name	RO-316233
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541222]
Structure		Download 2D MOL 3D MOL
Formula	C20H13N3O2
InChI	InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
InChIKey	DQYBRTASHMYDJG-UHFFFAOYSA-N
PubChem Compound ID	2399
PubChem Substance ID	6394913, 8032353, 8151606, 10319025, 14850845, 24891709, 26758309, 29221564, 47515128, 53788660, 53796028, 53800956, 57321301, 77857460, 85788013, 91589687, 99302640, 103036236, 103109123, 103165746, 104300473, 117357409, 121368925, 125333675, 126693737, 126695569, 127774231, 127774232, 134341611, 135060316, 135649488, 135684048, 136368441, 142222874, 143492699, 152059529, 152243629, 162032007, 163688523, 164045073, 164847311, 172093411, 172913015, 174484430, 175607394, 178102560, 179148410, 184593055, 186014368, 198990052
Target and Pathway
Target(s)	mRNA of PKC-epsilon	Target Info	Inhibitor	[527221]
	Protein kinase C, theta type	Target Info	Inhibitor	[528701]
	G2/mitotic-specific cyclin B1	Target Info	Inhibitor	[534788]
	Protein kinase C, alpha type	Target Info	Inhibitor	[528701]
	Protein kinase C, beta type	Target Info	Inhibitor	[528701]
	Protein kinase C, zeta type	Target Info	Inhibitor	[528701]
	Mitogen-activated protein kinase 11	Target Info	Inhibitor	[525872]
	Mitogen-activated protein kinase 14	Target Info	Inhibitor	[525872]
	RAC serine/threonine-protein kinase	Target Info	Inhibitor	[525872]
	Lck tyrosine kinase	Target Info	Inhibitor	[525872]
	Protein kinase C gamma type	Target Info	Inhibitor	[528701]
	CAMP-dependent protein kinase type I-alpha regulatory chain	Target Info	Inhibitor	[528701]
	Cell division control protein 2 homolog	Target Info	Inhibitor	[534788]
	NAD-dependent deacetylase sirtuin-1	Target Info	Inhibitor	[528556]
	Mitogen-activated protein kinase 8	Target Info	Inhibitor	[525872]
	Protein kinase C, delta type	Target Info	Inhibitor	[528701]
	Ribosomal protein S6 kinase	Target Info	Inhibitor	[525872]
	Serine/threonine-protein kinase Chk1	Target Info	Inhibitor	[525872]
	Rho-associated protein kinase 1	Target Info	Inhibitor	[525872]
	Protein kinase C, epsilon type	Target Info	Inhibitor	[528701]
	MAP kinase p38	Target Info	Inhibitor	[525872]
	Serine/threonine-protein kinase Sgk1	Target Info	Inhibitor	[525872]
	Mitogen-activated protein kinase 1	Target Info	Inhibitor	[525872]
KEGG Pathway	cGMP-PKG signaling pathway
	Sphingolipid signaling pathway
	Vascular smooth muscle contraction
	Tight junction
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	Inflammatory mediator regulation of TRP channels
	Type II diabetes mellitus
	MicroRNAs in cancerhsa04064:NF-kappa B signaling pathway
	T cell receptor signaling pathway
	Adipocytokine signaling pathway
	Measleshsa04068:FoxO signaling pathway
	Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	Progesterone-mediated oocyte maturationhsa04010:MAPK signaling pathway
	ErbB signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	HIF-1 signaling pathway
	Phosphatidylinositol signaling system
	mTOR signaling pathway
	PI3K-Akt signaling pathway
	Adrenergic signaling in cardiomyocytes
	Wnt signaling pathway
	VEGF signaling pathway
	Focal adhesion
	Gap junction
	Natural killer cell mediated cytotoxicity
	Leukocyte transendothelial migration
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Long-term depression
	Insulin secretion
	GnRH signaling pathway
	Melanogenesis
	Thyroid hormone synthesis
	Thyroid hormone signaling pathway
	Oxytocin signaling pathway
	Aldosterone-regulated sodium reabsorption
	Endocrine and other factor-regulated calcium reabsorption
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretion
	Amphetamine addiction
	Morphine addiction
	Vibrio cholerae infection
	Pathogenic Escherichia coli infection
	African trypanosomiasis
	Amoebiasis
	Hepatitis B
	Influenza A
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Glioma
	Non-small cell lung cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
B cell receptor signaling pathway
Carbohydrate digestion and absorption
Leishmaniasis
Choline metabolism in cancerhsa04015:Rap1 signaling pathway
Endocytosis
Hippo signaling pathway
Platelet activation
Insulin signaling pathway
Type II diabetes mellitushsa04010:MAPK signaling pathway
FoxO signaling pathway
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Epstein-Barr virus infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
cAMP signaling pathway
AMPK signaling pathway
Apoptosis
Jak-STAT signaling pathway
Estrogen signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Non-alcoholic fatty liver disease (NAFLD)
Measles
HTLV-I infection
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04064:NF-kappa B signaling pathway
Primary immunodeficiencyhsa04010:MAPK signaling pathway
Choline metabolism in cancerhsa04210:Apoptosis
Insulin signaling pathwayhsa04110:Cell cycle
Herpes simplex infection
Viral carcinogenesishsa04068:FoxO signaling pathway
MicroRNAs in cancerhsa04010:MAPK signaling pathway
Protein processing in endoplasmic reticulum
Choline metabolism in cancerhsa04062:Chemokine signaling pathway
Type II diabetes mellitushsa04012:ErbB signaling pathway
TGF-beta signaling pathway
Choline metabolism in cancerhsa04110:Cell cycle
Viral carcinogenesishsa04022:cGMP-PKG signaling pathway
Axon guidance
Regulation of actin cytoskeleton
MicroRNAs in cancerhsa04022:cGMP-PKG signaling pathway
Proteoglycans in cancerhsa04068:FoxO signaling pathway
Aldosterone-regulated sodium reabsorptionhsa04010:MAPK signaling pathway
Dorso-ventral axis formation
Adherens junction
Alzheimer's disease
Prion diseases
Alcoholism
Viral carcinogenesis
Thyroid cancer
Bladder cancer
Choline metabolism in cancer
NetPath Pathway	IL2 Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
	FSH Signaling Pathway
	TCR Signaling PathwayNetPath_23:TSH Signaling PathwayNetPath_11:TCR Signaling Pathway
	IL2 Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_21:RANKL Signaling PathwayNetPath_17:IL5 Signaling Pathway
	TNFalpha Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
	IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Alzheimer disease-amyloid secretase pathway
	Angiogenesis
	Apoptosis signaling pathway
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	VEGF signaling pathway
	Wnt signaling pathway
	5HT2 type receptor mediated signaling pathway
	Histamine H1 receptor mediated signaling pathway
	Oxytocin receptor mediated signaling pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
	T cell activation
	CCKR signaling map STP00059:p53 pathwayP00002:Alpha adrenergic receptor signaling pathway
	PDGF signaling pathway
	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
	B cell activation
	Metabotropic glutamate receptor group I pathway
	Thyrotropin-releasing hormone receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Interferon-gamma signaling pathway
	Oxidative stress response
	TGF-beta signaling pathway
	Ras Pathway
	p53 pathway feedback loops 2
	p38 MAPK pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Parkinson disease
	Toll receptor signaling pathway
	p38 MAPK pathway
	CCKR signaling map STP00005:Angiogenesis
	Huntington disease
	Hypoxia response via HIF activation
	Insulin/IGF pathway-protein kinase B signaling cascade
	Interleukin signaling pathway
	PI3 kinase pathway
	p53 pathway
	p53 pathway by glucose deprivation
	CCKR signaling map STP00049:Parkinson disease
	T cell activationP00002:Alpha adrenergic receptor signaling pathway
	Thyrotropin-releasing hormone receptor signaling pathwayP00019:Endothelin signaling pathway
	Hedgehog signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group II pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Transcription regulation by bZIP transcription factor
	GABA-B receptor II signalingP00059:p53 pathwayP00003:Alzheimer disease-amyloid secretase pathway
	FAS signaling pathway
	Integrin signalling pathway
	CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
	CCKR signaling map STP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	CCKR signaling map STP00016:Cytoskeletal regulation by Rho GTPase
	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	CCKR signaling map ST
Pathway Interaction Database	Endothelins
	LPA receptor mediated events
	TCR signaling in na&#xef
	LPA4-mediated signaling events
	CDC42 signaling events
	TCR signaling in na&#xef
	Thromboxane A2 receptor signaling
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	IL2-mediated signaling events
	PDGFR-beta signaling pathway
	IL8- and CXCR1-mediated signaling events
	Regulation of Ras family activation
	Downstream signaling in na&#xef
	Endothelins
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	p73 transcription factor network
	Validated targets of C-MYC transcriptional activation
	PLK1 signaling events
	FoxO family signaling
	Direct p53 effectors
	FOXM1 transcription factor network
	C-MYB transcription factor networkendothelinpathway:Endothelins
	Canonical NF-kappaB pathway
	Signaling events regulated by Ret tyrosine kinase
	mTOR signaling pathway
	Ras signaling in the CD4+ TCR pathway
	ErbB1 downstream signaling
	Syndecan-4-mediated signaling events
	ATF-2 transcription factor network
	Retinoic acid receptors-mediated signaling
	IL8- and CXCR2-mediated signaling events
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
	a6b1 and a6b4 Integrin signaling
	Fc-epsilon receptor I signaling in mast cells
	JNK signaling in the CD4+ TCR pathway
	RhoA signaling pathway
	Insulin Pathway
	Noncanonical Wnt signaling pathway
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	IL1-mediated signaling events
	CXCR4-mediated signaling events
	IGF1 pathway
	TNF receptor signaling pathway
	IL2 signaling events mediated by PI3K
	Ceramide signaling pathway
	p75(NTR)-mediated signaling
	amb2 Integrin signaling
	Neurotrophic factor-mediated Trk receptor signaling
	Nephrin/Neph1 signaling in the kidney podocyte
	Insulin-mediated glucose transport
	Regulation of Ras family activationp73pathway:p73 transcription factor network
	p38 MAPK signaling pathway
	Plasma membrane estrogen receptor signaling
	CD40/CD40L signaling
	Regulation of p38-alpha and p38-beta
	FAS (CD95) signaling pathway
	Glucocorticoid receptor regulatory network
	Rapid glucocorticoid signaling
	IL6-mediated signaling events
	p38 signaling mediated by MAPKAP kinases
	CXCR3-mediated signaling events
	Signaling mediated by p38-alpha and p38-beta
VEGFR3 signaling in lymphatic endothelium
Regulation of retinoblastoma proteinendothelinpathway:Endothelins
BCR signaling pathway
p73 transcription factor network
Atypical NF-kappaB pathway
IL4-mediated signaling events
IL12-mediated signaling events
Angiopoietin receptor Tie2-mediated signaling
Regulation of Androgen receptor activity
EPO signaling pathway
p53 pathway
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
FGF signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Fc-epsilon receptor I signaling in mast cells
Signaling events mediated by PTP1B
S1P3 pathway
Coregulation of Androgen receptor activity
Reelin signaling pathway
Integrin-linked kinase signaling
Regulation of Telomerase
FOXA2 and FOXA3 transcription factor networks
E-cadherin signaling in the nascent adherens junction
Integrins in angiogenesis
IFN-gamma pathway
ErbB2/ErbB3 signaling events
E-cadherin signaling in keratinocytes
Signaling events mediated by the Hedgehog family
Nongenotropic Androgen signaling
Hedgehog signaling events mediated by Gli proteins
Caspase Cascade in Apoptosis
Signaling events mediated by Stem cell factor receptor (c-Kit)
Aurora A signaling
Class I PI3K signaling events mediated by Akt
HIF-1-alpha transcription factor network
Trk receptor signaling mediated by PI3K and PLC-gamma
FGF signaling pathwaynfkappabatypicalpathway:Atypical NF-kappaB pathway
Glypican 1 network
SHP2 signaling
Class I PI3K signaling events
EPHA forward signaling
IL2 signaling events mediated by STAT5
Ephrin B reverse signaling
Alpha-synuclein signalingendothelinpathway:Endothelins
IL8- and CXCR1-mediated signaling eventsintegrin_a4b1_pathway:Alpha4 beta1 integrin signaling eventsp73pathway:p73 transcription factor network
E2F transcription factor network
AP-1 transcription factor network
Retinoic acid receptors-mediated signalingp73pathway:p73 transcription factor network
Signaling events mediated by HDAC Class III
HIF-2-alpha transcription factor network
Signaling events mediated by HDAC Class I
Regulation of retinoblastoma proteinfcer1pathway:Fc-epsilon receptor I signaling in mast cells
RhoA signaling pathway
Osteopontin-mediated events
TRAIL signaling pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Syndecan-2-mediated signaling events
N-cadherin signaling events
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4endothelinpathway:Endothelins
Validated transcriptional targets of TAp63 isoforms
Alpha-synuclein signalinginsulin_pathway:Insulin Pathway
RXR and RAR heterodimerization with other nuclear receptor
TGF-beta receptor signalingfanconi_pathway:Fanconi anemia pathway
ATR signaling pathway
Circadian rhythm pathway
p53 pathwayprlsignalingeventspathway:Signaling events mediated by PRL
EPHB forward signaling
PAR4-mediated thrombin signaling events
Stabilization and expansion of the E-cadherin adherens junction
N-cadherin signaling eventsendothelinpathway:Endothelins
Signaling mediated by p38-gamma and p38-deltainsulin_pathway:Insulin Pathway
Class I PI3K signaling eventsfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Signaling events mediated by PRL
ErbB4 signaling events
GMCSF-mediated signaling events
S1P4 pathway
Presenilin action in Notch and Wnt signaling
S1P1 pathway
Netrin-mediated signaling events
Arf6 downstream pathway
Class IB PI3K non-lipid kinase events
EGF receptor (ErbB1) signaling pathway
BMP receptor signaling
ALK1 signaling events
Syndecan-1-mediated signaling events
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Cellular roles of Anthrax toxin
Alpha-synuclein signaling
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast Cells
	Activation of PKC through G protein coupled receptorPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
	Insulin Signalling
	Leucine Stimulation on Insulin SignalingPW000564:Muscle/Heart ContractionPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Fc Epsilon Receptor I Signaling in Mast CellsPW000659:Leucine Stimulation on Insulin SignalingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome	Effects of PIP2 hydrolysis
	DAG and IP3 signaling
	Role of phospholipids in phagocytosis
	G alpha (z) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
	Inactivation, recovery and regulation of the phototransduction cascade
	FCERI mediated NF-kB activation
	G alpha (z) signalling eventsR-HSA-156711:Polo-like kinase mediated events
	Golgi Cisternae Pericentriolar Stack Reorganization
	Regulation of APC/C activators between G1/S and early anaphase
	Phosphorylation of the APC/C
	Phosphorylation of Emi1
	Condensation of Prophase Chromosomes
	MASTL Facilitates Mitotic Progression
	Resolution of Sister Chromatid Cohesion
	Condensation of Prometaphase Chromosomes
	Regulation of PLK1 Activity at G2/M Transition
	Activation of NIMA Kinases NEK9, NEK6, NEK7
	Recruitment of NuMA to mitotic centrosomes
	Depolymerisation of the Nuclear Lamina
	Cyclin A/B1 associated events during G2/M transition
	G2/M DNA replication checkpoint
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-111933:Calmodulin induced events
	Disinhibition of SNARE formation
	Regulation of KIT signaling
	EGFR Transactivation by Gastrin
	Syndecan interactions
	Acetylcholine regulates insulin secretion
	Ca2+ pathway
	Trafficking of GluR2-containing AMPA receptors
	G alpha (z) signalling events
	HuR (ELAVL1) binds and stabilizes mRNA
	WNT5A-dependent internalization of FZD4
	VEGFR2 mediated cell proliferation
	Response to elevated platelet cytosolic Ca2+R-HSA-114516:Disinhibition of SNARE formation
	Activation of NF-kappaB in B cells
	Response to elevated platelet cytosolic Ca2+R-HSA-114604:GPVI-mediated activation cascade
	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
	VEGFR2 mediated cell proliferationR-HSA-168638:NOD1/2 Signaling Pathway
	p38MAPK events
	ERK/MAPK targets
	Activation of PPARGC1A (PGC-1alpha) by phosphorylation
	Oxidative Stress Induced Senescence
	CDO in myogenesis
	DSCAM interactions
	VEGFA-VEGFR2 Pathway
	activated TAK1 mediates p38 MAPK activation
	Activation of the AP-1 family of transcription factors
	KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
	ADP signalling through P2Y purinoceptor 1
	Platelet sensitization by LDL
	KSRP (KHSRP) binds and destabilizes mRNAR-HSA-111447:Activation of BAD and translocation to mitochondria
	GPVI-mediated activation cascade
	PIP3 activates AKT signaling
	Translocation of GLUT4 to the plasma membrane
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	AKT phosphorylates targets in the cytosol
	AKT phosphorylates targets in the nucleus
	Negative regulation of the PI3K/AKT network
	eNOS activation
	AKT-mediated inactivation of FOXO1A
	Integrin alphaIIb beta3 signaling
	Deactivation of the beta-catenin transactivating complex
	CD28 dependent PI3K/Akt signaling
	CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in CancerR-HSA-114604:GPVI-mediated activation cascade
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent Vav1 pathway
PD-1 signaling
Interleukin-2 signalingR-HSA-111933:Calmodulin induced events
Response to elevated platelet cytosolic Ca2+R-HSA-163615:PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog 'off' state
Factors involved in megakaryocyte development and platelet productionR-HSA-110056:MAPK3 (ERK1) activation
E2F mediated regulation of DNA replication
G0 and Early G1
Cyclin B2 mediated events
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
G1/S-Specific Transcription
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-1368082:RORA activates gene expression
Regulation of HSF1-mediated heat shock response
Circadian ClockR-HSA-193648:NRAGE signals death through JNK
NRIF signals cell death from the nucleus
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-111465:Apoptotic cleavage of cellular proteins
Calmodulin induced events
CLEC7A (Dectin-1) signaling
Interferon gamma signalingR-HSA-166208:mTORC1-mediated signallingR-HSA-176187:Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-111465:Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases Activate ROCKsR-HSA-114508:Effects of PIP2 hydrolysis
G alpha (z) signalling eventsR-HSA-168638:NOD1/2 Signaling Pathway
VEGFA-VEGFR2 PathwayR-HSA-2672351:Stimuli-sensing channelsR-HSA-112409:RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Regulation of actin dynamics for phagocytic cup formation
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signaling
WikiPathways	Hypothetical Network for Drug Addiction
	Calcium Regulation in the Cardiac Cell
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Oncostatin M Signaling Pathway
	miRs in Muscle Cell Differentiation
	GPCR downstream signaling
	Effects of PIP2 hydrolysis
	Physiological and Pathological Hypertrophy of the HeartWP69:TCR Signaling Pathway
	Insulin Signaling
	Fc epsilon receptor (FCERI) signaling
	Corticotropin-releasing hormone
	Signaling Pathways in Glioblastoma
	TCR signaling
	Netrin-1 signaling
	Apoptotic execution phaseWP707:DNA Damage Response
	G1 to S cell cycle control
	Mitotic Prophase
	Mitotic Prometaphase
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	Cell Cycle
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage Response
	AMPK SignalingWP673:ErbB Signaling Pathway
	EGF/EGFR Signaling Pathway
	Wnt Signaling Pathway Netpath
	Kit receptor signaling pathway
	Transcriptional activation by NRF2
	Human Complement System
	Cardiac Hypertrophic Response
	Syndecan interactions
	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	Signaling by SCF-KIT
	DAG and IP3 signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	T-Cell Receptor and Co-stimulatory Signaling
	Alpha 6 Beta 4 signaling pathway
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	AGE/RAGE pathway
	Pathogenic Escherichia coli infection
	Endothelin Pathways
	Regulation of Microtubule Cytoskeleton
	FSH signaling pathway
	Opioid Signalling
	Response to elevated platelet cytosolic Ca2+
	Integration of energy metabolism
	TOR SignalingWP536:Calcium Regulation in the Cardiac Cell
	MAPK Signaling Pathway
	Signaling by the B Cell Receptor (BCR)
	B Cell Receptor Signaling Pathway
	MicroRNAs in cardiomyocyte hypertrophy
	Physiological and Pathological Hypertrophy of the HeartWP536:Calcium Regulation in the Cardiac Cell
	Signaling by TGF-beta Receptor Complex
	Allograft Rejection
	TNF alpha Signaling Pathway
	IL-1 signaling pathway
	GPVI-mediated activation cascade
Type II diabetes mellitusWP75:Toll-like receptor signaling pathway
IL-4 Signaling Pathway
MAP kinase activation in TLR cascade
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Parkinsons Disease Pathway
NGF signalling via TRKA from the plasma membrane
Myogenesis
DSCAM interactions
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Interferon type I signaling pathways
MAPK Cascade
Oxidative Stress
p38 MAPK Signaling Pathway
TGF beta Signaling Pathway
JAK/STAT
Amyotrophic lateral sclerosis (ALS)
Cardiac Progenitor Differentiation
BDNF signaling pathway
Prostate Cancer
TSLP Signaling Pathway
TWEAK Signaling Pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Signal amplification
Platelet homeostasis
Angiogenesis
DNA Damage Response (only ATM dependent)
Notch Signaling Pathway
EPO Receptor Signaling
IL-2 Signaling Pathway
Endochondral Ossification
IL-6 signaling pathway
Copper homeostasis
Extracellular vesicle-mediated signaling in recipient cells
Apoptosis-related network due to altered Notch3 in ovarian cancer
IL-3 Signaling Pathway
Translocation of GLUT4 to the Plasma Membrane
PIP3 activates AKT signaling
Signal Transduction of S1P Receptor
Primary Focal Segmental Glomerulosclerosis FSGS
Apoptosis
Interleukin-11 Signaling Pathway
IL17 signaling pathway
IL-7 Signaling Pathway
TSH signaling pathway
Integrated Breast Cancer Pathway
SREBP signalling
Integrated Cancer pathway
Metabolism of nitric oxide
Integrin-mediated Cell Adhesion
TFs Regulate miRNAs related to cardiac hypertrophy
TOR Signaling
Regulation of toll-like receptor signaling pathway
AMPK Signaling
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP61:Notch Signaling Pathway
Inflammatory Response Pathway
DAP12 interactions
Host Interactions of HIV factors
Costimulation by the CD28 familyWP536:Calcium Regulation in the Cardiac Cell
Response to elevated platelet cytosolic Ca2+WP706:SIDS Susceptibility Pathways
Mesodermal Commitment Pathway
Regulation of Water Balance by Renal Aquaporins
Factors involved in megakaryocyte development and platelet productionWP707:DNA Damage Response
PPAR Alpha Pathway
RAF/MAP kinase cascade
BMI1
miRNA Regulation of DNA Damage ResponseWP2377:Integrated Pancreatic Cancer Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Androgen receptor signaling pathwayWP75:Toll-like receptor signaling pathway
ErbB Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Signaling of Hepatocyte Growth Factor Receptor
NLR Proteins
EBV LMP1 signaling
PDGF Pathway
Nanoparticle triggered regulated necrosis
Signalling by NGF
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
Type II diabetes mellitus
Osteoclast SignalingWP69:TCR Signaling Pathway
Type II interferon signaling (IFNG)
Apoptotic execution phase
Type II diabetes mellitusWP673:ErbB Signaling Pathway
G13 Signaling Pathway
Cytoplasmic Ribosomal Proteins
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by Insulin receptor
IL-5 Signaling PathwayWP707:DNA Damage Response
miRNA Regulation of DNA Damage ResponseWP524:G13 Signaling Pathway
Regulation of Actin Cytoskeleton
Focal Adhesion
Semaphorin interactions
Androgen receptor signaling pathwayWP666:Hypothetical Network for Drug Addiction
Physiological and Pathological Hypertrophy of the HeartWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathwayWP481:Insulin Signaling
Iron uptake and transport
FSH signaling pathwayWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Vitamin A and Carotenoid Metabolism
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Bladder Cancer
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Genes and (Common) Pathways Underlying Drug Addiction
Nifedipine Activity
Aryl Hydrocarbon Receptor
IL-9 Signaling Pathway
Alzheimers Disease
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by FGFR
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Heart Development
Osteopontin Signaling
IL-5 Signaling Pathway
References
Ref 541222	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5937).
Ref 525872	Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Ref 527221	Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4.Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.
Ref 528556	J Med Chem. 2006 Dec 14;49(25):7307-16.Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Ref 528701	J Med Chem. 1992 Jan;35(1):177-84.Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.
Ref 534788	Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.

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