Drug Information

Drug General Information
Drug ID
D0LF5B
Former ID
DIB015572
Drug Name
KN-38-7271
Synonyms
Cannabinoid 1/2 receptor agonists (cerebrovascular ischemia/pain), Bayer; Cannabinoid 1/2 receptor agonists (traumatic brain injury/stroke), KeyNeurotek
Indication Ischemia [ICD9: 459.89; ICD10:I99.8] Discontinued in Phase 2 [547265]
Company
Bayer AG
Structure
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2D MOL

3D MOL
Canonical SMILES
O=S(=O)(Oc1cccc(c1)Oc1cccc2C[C@H](Cc12)CO)CCCC(F)(F)F
CAS Number
CAS 212188-60-8
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Modulator
Cannabinoid receptor 1 Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 547265Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014615)

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