Drug Information

Drug General Information
Drug ID
D0LO5B
Former ID
DIB021056
Drug Name
THZ1
Synonyms
HY-80013
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532889]
Structure
Download
2D MOL
Formula
C31H28ClN7O2
InChI
InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+
InChIKey
OBJNFLYHUXWUPF-IZZDOVSWSA-N
PubChem Compound ID
73602827
PubChem Substance ID
176482697, 210279131, 210281456, 239943899, 249565732, 252451412
Target and Pathway
Target(s) Cell division protein kinase 7 Target Info Inhibitor [532889]
KEGG Pathway Basal transcription factors
Nucleotide excision repair
Cell cycle
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome NoRC negatively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
RNA Polymerase I Transcription Initiation
WikiPathways G1 to S cell cycle control
Eukaryotic Transcription Initiation
Cardiac Hypertrophic Response
S Phase
HIV Life Cycle
Integrated Breast Cancer Pathway
Nucleotide Excision Repair
RNA Polymerase II Transcription
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
mRNA Capping
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 532889Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.
Ref 532889Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.

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