Drug Information

Drug General Information
Drug ID
D0LR0R
Former ID
DAP001070
Drug Name
Methdilazine
Synonyms
Disyncram; Methdilazinum; Methodilazine; Metodilazina; Tacaryl; Tacazyl; Tacryl; Methilazine hydrochloride; Methdilazine (INN); Methdilazinum [INN-Latin]; Metodilazina [INN-Spanish]; Tacaryl (TN); Methdilazine [USAN:INN:BAN]; 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine; 10-((1-methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine; 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine; 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [542247], [550689]
Therapeutic Class
Antihistamines
Structure
Download
2D MOL

3D MOL
Formula
C18H20N2S
InChI
InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3
InChIKey
HTMIBDQKFHUPSX-UHFFFAOYSA-N
CAS Number
CAS 1982-37-2
PubChem Compound ID
14677
PubChem Substance ID
9384, 135654, 647047, 7593023, 8161076, 10319677, 10512529, 11405746, 14751550, 29282717, 46505472, 47206710, 48035414, 48259508, 48416241, 49855141, 57328680, 79551326, 85209817, 103770942, 104335139, 117404375, 128111044, 131342044, 134338327, 134982817, 137101853, 141522707, 160964241, 176262319, 178103805, 179116778, 184528625, 223440310, 224019337, 226492957, 249964340
SuperDrug ATC ID
R06AD04
SuperDrug CAS ID
cas=001982372
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537703]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 542247(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7231).
Ref 550689Drug information of Methdilazine, 2008. eduDrugs.
Ref 537703Effect of H1 blockers alone and in combination with morphine to produce antinociception in mice. Neuropharmacology. 1985 Jan;24(1):1-4.

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