Drug Information

Drug General Information
Drug ID
D0LX4U
Former ID
DNC007318
Drug Name
1-[bis(4-bromophenyl)methyl]-3-phenylthiourea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527861]
Structure
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2D MOL

3D MOL
Formula
C20H16Br2N2S
Canonical SMILES
C1=CC=C(C=C1)NC(=S)NC(C2=CC=C(C=C2)Br)C3=CC=C(C=C3)Br
InChI
1S/C20H16Br2N2S/c21-16-10-6-14(7-11-16)19(15-8-12-17(22)13-9-15)24-20(25)23-18-4-2-1-3-5-18/h1-13,19H,(H2,23,24,25)
InChIKey
JQWBRSQRBYVWFQ-UHFFFAOYSA-N
PubChem Compound ID
11576518
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [527861]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527861J Med Chem. 2005 Nov 17;48(23):7486-90.1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.
Ref 527861J Med Chem. 2005 Nov 17;48(23):7486-90.1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.

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