Drug Information

Drug General Information
Drug ID
D0LZ5R
Former ID
DIB021007
Drug Name
T0156
Synonyms
T-0156
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540738]
Structure
Download
2D MOL
Formula
C31H29N5O7
InChI
InChI=1S/C31H29N5O7/c1-18-13-19(7-11-32-18)16-36-27(31(38)42-5)25(20-14-22(39-2)28(41-4)23(15-20)40-3)21-8-12-35-29(26(21)30(36)37)43-17-24-33-9-6-10-34-24/h6-15H,16-17H2,1-5H3
InChIKey
JEMJAABFSYOLAP-UHFFFAOYSA-N
PubChem Compound ID
5368
PubChem Substance ID
7685343, 8153301, 11111926, 11114178, 15319915, 29224420, 48035265, 48185116, 50104931, 76864593, 85787159, 104021476, 104309038, 123097018, 124750323, 124881740, 124881741, 138533732, 141467882, 162963491, 178101958, 226981133, 246918186
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [526468]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 540738(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5275).
Ref 526468Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol. 2002 Dec 5;456(1-3):91-8.

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