Drug Information

Drug General Information
Drug ID
D0M0OT
Former ID
DNCL002718
Drug Name
Leukemia cancer vaccine
Synonyms
GVAX (TN)
Drug Type
Vaccine
Indication Acute myeloid leukemia; Chronic myeloid leukemia [ICD9: 205.0, 205.1, 238.7; ICD10:C92.0, C92.1, D46] Phase 2 [524918]
Company
BioSante Pharmaceuticals
Target and Pathway
Target(s) Granulocyte-macrophage colony-stimulating factor receptor alpha chain Target Info [543463]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway IL3 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Alpha9 beta1 integrin signaling events
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Surfactant metabolism
Interleukin receptor SHC signaling
WikiPathways Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 524918ClinicalTrials.gov (NCT02243371) GVAX Pancreas Vaccine (With CY) and CRS-207 With or Without Nivolumab. U.S. National Institutes of Health.
Ref 543463(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707).

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