Drug General Information
Drug ID
D0M3IN
Former ID
DCL000293
Drug Name
Xanthine
Drug Type
Small molecular drug
Indication Apnea [ICD9: 786.03; ICD10:R06.81] Phase 1 [467794], [527315]
Company
Schering-Plough
Structure
Download
2D MOL

3D MOL

Formula
C5H4N4O2
InChIKey
LRFVTYWOQMYALW-UHFFFAOYSA-N
CAS Number
CAS 69-89-6
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:17712
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [535254]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467794(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4557).
Ref 527315Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1111-6.
Ref 535254Role of adenosine in asthma. Drug Dev Res. 1996;39:333-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.