Drug General Information
Drug ID
Former ID
Drug Name
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Discontinued in Phase 1/2 [548938]
Kyowa Hakko Kirin Pharma
Target and Pathway
Target(s) Insulin-like growth factor I receptor Target Info Modulator [1572591]
Insulin receptor Target Info Modulator [1572591]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
PI3K-Akt signaling pathway
AMPK signaling pathway
Focal adhesion
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Prostate cancer
Melanomahsa04014:Ras signaling pathway
cGMP-PKG signaling pathway
Insulin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascadeP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
PI3 kinase pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junctioninsulin_pathway:Insulin Pathway
Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Insulin-mediated glucose transport
PathWhiz Pathway Insulin Signalling
Leucine Stimulation on Insulin Signaling
Reactome IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1RR-HSA-74713:IRS activation
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor recycling
WikiPathways Senescence and Autophagy in Cancer
Insulin Signaling
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling Pathways in Glioblastoma
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophyWP710:DNA Damage Response (only ATM dependent)
Nanoparticle triggered autophagic cell death
AGE/RAGE pathway
Signaling by Insulin receptor
Folate Metabolism
Type II diabetes mellitus
Vitamin B12 Metabolism
Selenium Micronutrient Network
AMPK Signaling
Ref 548938Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030562)
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.