Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M3PG
|
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| Former ID |
DNC005894
|
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| Drug Name |
6,7-dihydroxy-8-nitro-1-tetralone
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C10H9NO5
|
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| Canonical SMILES |
C1CC2=CC(=C(C(=C2C(=O)C1)[N+](=O)[O-])O)O
|
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| InChI |
1S/C10H9NO5/c12-6-3-1-2-5-4-7(13)10(14)9(8(5)6)11(15)16/h4,13-14H,1-3H2
|
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| InChIKey |
CXOQHHVPOJWTNP-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Catechol-O-methyl-transferase | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | L-dopa degradation | ||||
| Dopamine degradation | |||||
| Noradrenaline and adrenaline degradation | |||||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Tyrosine metabolism | |||||
| Metabolic pathways | |||||
| Dopaminergic synapse | |||||
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Dopamine receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Tyrosine Metabolism | ||||
| WikiPathways | Methylation Pathways | ||||
| Metapathway biotransformation | |||||
| Estrogen metabolism | |||||
| Biogenic Amine Synthesis | |||||
| Dopamine metabolism | |||||
| Phase II conjugation | |||||
| Neurotransmitter Clearance In The Synaptic Cleft | |||||
| References | |||||
| REF 1 | J Med Chem. 2005 Dec 15;48(25):8070-8.Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase. | ||||
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