Drug Information

Drug General Information
Drug ID
D0M3TD
Former ID
DIB002958
Drug Name
Org-43902
Synonyms
LH-ago1; ORG-41247; ORG-42619; ORG-43311; SC-20565; Luteinizing hormone receptor (LHR) agonist, NV Organon; Oral LH agonist, Schering-Plough; Low molecular weight luteinizing hormone (LMW LH) receptor agonist, Merck & Co; Luteinizing hormone agonist (oral), Merck & Co; Luteinizing hormone agonist (oral), Schering-Plough
Indication Infertility [ICD9: 628; ICD10:N97.0] Phase 1 [549583]
Company
Organon BioSciences
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1(c(c2c(s1)nc(nc2c1cc(OC)ccc1)SC)N)C(=O)NC(C)(C)C
CAS Number
CAS 301847-37-0
Target and Pathway
Target(s) Lutropin-choriogonadotropic hormone receptor Target Info Agonist [532276]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Ovarian steroidogenesis
Prolactin signaling pathway
NetPath Pathway FSH Signaling Pathway
Pathway Interaction Database Arf6 signaling events
PathWhiz Pathway Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
Reactome Hormone ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 549583Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800042073)
Ref 532276First evidence of ovulation induced by oral LH agonists in healthy female volunteers of reproductive age. J Clin Endocrinol Metab. 2013 Apr;98(4):1558-66.

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