Drug Information

Drug General Information
Drug ID
D0M3XR
Former ID
DNCL002892
Drug Name
MK-3102
Synonyms
Omarigliptin
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 3 [524091], [543109]
Company
Merck
Structure
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2D MOL

3D MOL
Formula
C17H20F2N4O3S
InChI
InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1
InChIKey
MKMPWKUAHLTIBJ-ISTRZQFTSA-N
PubChem Compound ID
46209133
PubChem Substance ID
96063383, 120474876, 160698096, 162108671, 163312347, 170504829, 198953034, 223404367, 223471398, 224386673, 227101694, 242056369, 242680010, 249733358, 249815950, 251966556, 252151226, 252166612, 252215818, 252510734, 252810247
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Modulator [532717]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 524091ClinicalTrials.gov (NCT01703208) A Study to Assess Cardiovascular Outcomes Following Treatment With MK-3102 in Participants With Type 2 Diabetes Mellitus (MK-3102-018). U.S. National Institutes of Health.
Ref 543109(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8402).
Ref 532717Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem. 2014 Apr 24;57(8):3205-12.

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