Drug Information

Drug General Information
Drug ID
D0M4WA
Former ID
DIB018023
Drug Name
obeticholic acid
Synonyms
INT747; INT-747; 6-ethylchenodeoxycholic acid; 6-ECDCA; OCA; 6-Et CDCA
Drug Type
Small molecular drug
Indication Primary biliary cholangitis [ICD10:K00-K95] Approved [889440]
Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Clinical trial [526211]
Company
Intercept
Structure
Download
2D MOL
Formula
C26H44O4
InChI
InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
InChIKey
ZXERDUOLZKYMJM-ZWECCWDJSA-N
PubChem Compound ID
447715
PubChem Substance ID
828938, 828951, 7886586, 7888489, 10300105, 14880306, 16101459, 17396626, 36889785, 46392814, 49700782, 53789454, 57404826, 76486275, 96026040, 103700141, 104638392, 123055342, 126680398, 135263637, 163122223, 175265866, 176236560, 178100437, 204383201, 219813737, 223670674, 224721644, 227005340, 251970994, 252300974, 252553933
Target and Pathway
Target(s) Bile acid receptor Target Info Modulator [889440]
KEGG Pathway Bile secretion
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome Recycling of bile acids and salts
PPARA activates gene expression
Endogenous sterols
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
Drug Induction of Bile Acid Pathway
References
Ref 526211Nuclear receptors and lipid physiology: opening the X-files. Science. 2001 Nov 30;294(5548):1866-70.
Ref 8894402016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.
Ref 8894402016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.

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