Drug Information

Drug General Information
Drug ID
D0M5WS
Former ID
DNCL002874
Drug Name
JNJ-16269110
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 2 [522314]
Company
Janssen Research & Development
Structure
Download
2D MOL

3D MOL
Formula
C34H31F3N2O3
Canonical SMILES
COC(=O)C(C1=CC=CC=C1)N2CCC(CC2)C3=CC=C(C=C3)NC(=O)C4=CC<br />=CC=C4C5=CC=C(C=C5)C(F)(F)F
InChI
1S/C34H31F3N2O3/c1-42-33(41)31(26-7-3-2-4-8-26)39-21-19-24(20-22-39)23-13-17-28(18-14-23)38-32(40)30-10-6-5-9-29(30)25-11-15-27(16-12-25)34(35,36)37/h2-18,24,31H,19-22H2,1H3,(H,38,40)/t31-/m0/s1
InChIKey
WSYALRNYQFNNGP-HKBQPEDESA-N
PubChem Compound ID
46894104
PubChem Substance ID
99346607, 120909883, 160671037, 227081860, 244841397
Target and Pathway
Target(s) Microsomal triglyceride transfer protein, large subunit Target Info Inhibitor [522314]
KEGG Pathway Fat digestion and absorption
Reactome Chylomicron-mediated lipid transport
WikiPathways Statin Pathway
Lipid digestion, mobilization, and transport
References
Ref 522314ClinicalTrials.gov (NCT00672386) A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes. U.S. National Institutes of Health.
Ref 522314ClinicalTrials.gov (NCT00672386) A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes. U.S. National Institutes of Health.

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