TTD | Drug: D0M6OV

Drug General Information
Drug ID	D0M6OV
Former ID	DIB020142
Drug Name	KOS1326
Synonyms	4'' deoxy EM-A enolether
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538922]
Structure		Download 2D MOL
Formula	C37H65NO11
InChI	InChI=1S/C37H65NO11/c1-14-26-37(10,42)31(40)22(5)29-19(2)16-36(9,49-29)32(48-34-28(39)25(38(11)12)15-20(3)45-34)23(6)30(24(7)33(41)46-26)47-27-18-35(8,43-13)17-21(4)44-27/h20-28,30-32,34,39-40,42H,14-18H2,1-13H3/t20-,21+,22+,23+,24-,25+,26-,27+,28-,30+,31-,32-,34+,35+,36-,37-/m1/s1
InChIKey	UJUXMUPAZCCNTJ-ANUGEFLXSA-N
PubChem Compound ID	10259168
PubChem Substance ID	15262543, 53841119, 79659916, 103235283, 135652697
Target and Pathway
Target(s)	Motilin receptor	Target Info	Agonist	[527468]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538922	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1446).
Ref 527468	Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. Epub 2005 Mar 11.

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Drug Information