Drug Information

Drug General Information
Drug ID
D0M6VZ
Former ID
DIB018055
Drug Name
(-)-englerin A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530973]
Structure
Download
2D MOL
Formula
C26H34O6
InChI
InChI=1S/C26H34O6/c1-16(2)26-14-20(30-22(29)15-27)25(4,32-26)19-12-10-17(3)23(19)24(26)31-21(28)13-11-18-8-6-5-7-9-18/h5-9,11,13,16-17,19-20,23-24,27H,10,12,14-15H2,1-4H3/b13-11+/t17-,19-,20-,23-,24+,25+,26-/m1/s1
InChIKey
GACOFEKSDCOVMV-RRYXBOBMSA-N
PubChem Compound ID
46242512
PubChem Substance ID
96104426, 160705191, 160962934, 237369179, 249737697, 252166584
Target and Pathway
Target(s) TRP cation channel C5 Target Info Agonist [533149]
TRPC4 Target Info Agonist [533149]
PANTHER Pathway Alzheimer disease-presenilin pathway
Reactome TRP channels
Role of second messengers in netrin-1 signaling
WikiPathways Netrin-1 signaling
References
Ref 530973Enantioselective synthesis of (-)-englerins A and B. Angew Chem Int Ed Engl. 2010 May 3;49(20):3517-9.
Ref 533149(-)-Englerin?? is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91.

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