Drug Information

Drug General Information
Drug ID
D0M7HQ
Former ID
DNC006589
Drug Name
4-isopropyl-N-(naphthalen-1-yl)thiazol-2-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528047]
Structure
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2D MOL

3D MOL
Formula
C16H16N2S
Canonical SMILES
CC(C)C1=CSC(=N1)NC2=CC=CC3=CC=CC=C32
InChI
1S/C16H16N2S/c1-11(2)15-10-19-16(18-15)17-14-9-5-7-12-6-3-4-8-13(12)14/h3-11H,1-2H3,(H,17,18)
InChIKey
UZYASSJTIRFKFN-UHFFFAOYSA-N
PubChem Compound ID
9814022
Target and Pathway
Target(s) C-Cchemokine receptor type 4 Target Info Inhibitor [528047]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528047Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.
Ref 528047Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. Epub 2006 Feb 23.Optimization of 2-aminothiazole derivatives as CCR4 antagonists.

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