Drug General Information
Drug ID
D0M8BE
Former ID
DIB002395
Drug Name
TgAAV-TNFR:Fc
Synonyms
TgAAC-94; AAV-huTNFR:Fc; Gene therapy (rheumatoid arthritis), Targeted Genetics; RAAV-TNF, Targeted Genetics; RAAV2-TNFR:Fc
Drug Type
Small molecular drug
Indication Inflammatory disorder Phase 1/2 [527270]
Company
Targeted Genetics
Structure
Download
2D MOL

3D MOL

Formula
C20H29N5O3
Canonical SMILES
CN1C(=CC(=O)N(C1=O)C)NCCCN2CCN(CC2)C3=CC=CC=C3OC
InChI
1S/C20H29N5O3/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3/h4-5,7-8,15,21H,6,9-14H2,1-3H3
InChIKey
ICMGLRUYEQNHPF-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) TNF receptor Target Info Modulator
References
Ref 527270Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.

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