TTD | Drug: D0M9RQ

Drug General Information
Drug ID	D0M9RQ
Former ID	DIB018030
Drug Name	MK-0249
Synonyms	MK 0249; MK0249
Drug Type	Small molecular drug
Indication	Obese insulin-resistant disorders [ICD9: 250; ICD10:E11]		Clinical trial	[532558]
Structure		Download 2D MOL
Formula	C23H24F3N3O2
InChI	InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3
InChIKey	DDDZBLNULGDPGA-UHFFFAOYSA-N
PubChem Compound ID	11697697
PubChem Substance ID	16802207, 23790983, 42864610, 78024872, 103624012, 104111462, 135317343, 137069949, 141049975, 141627966, 178103918, 198937202, 202535657, 224274612, 226491325, 242981278
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Agonist	[529576]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 532558	(11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists. J Nucl Med. 2014 Jan;55(1):65-72.
Ref 529576	Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists. J Med Chem. 2008 Aug 14;51(15):4780-9.

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Drug Information