Drug General Information
Drug ID
D0M9RQ
Former ID
DIB018030
Drug Name
MK-0249
Synonyms
MK 0249; MK0249
Drug Type
Small molecular drug
Indication Obese insulin-resistant disorders [ICD9: 250; ICD10:E11] Clinical trial [532558]
Structure
Download
2D MOL
Formula
C23H24F3N3O2
InChI
InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3
InChIKey
DDDZBLNULGDPGA-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Histamine H3 receptor Target Info Agonist [529576]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 532558(11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists. J Nucl Med. 2014 Jan;55(1):65-72.
Ref 529576Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists. J Med Chem. 2008 Aug 14;51(15):4780-9.

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