Drug Information

Drug General Information
Drug ID
D0M9WM
Former ID
DAP000605
Drug Name
Chlorothiazide
Synonyms
Aldoclor; Alurene; Chloriazid; Chlorosal; Chlorothiazid; Chlorothiazidum; Chlorotiazida; Chlorthiazid; Chlorthiazide; Chlorthiazidum; Chlortiazid; Chlorurit; Chlotride; Chlrosal; Clorotiazida; Clorotiazide; Clotride; Diupres; Diuresal; Diuril; Diurilix; Diurite; Diutrid; Flumen; Minzil; Salisan; Salunil; Saluretil; Saluric; Thiazide; Urinex; Warduzide; Yadalan; Clorotiazide [DCIT]; Component of Aldoclor; Diuril Boluses; C 4911; Chlorothiazidum [INN-Latin]; Clorotiazida [INN-Spanish]; Diuril (TN); Diuril Boluses, Veterinary; Neo-Dema; Sk-chlorothiazide; Chlorothiazide [USAN:INN:BAN]; Diuril, Chlotride, Chlorothiazide; Chlorothiazide (JAN/USP/INN); 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide; 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Drug Type
Small molecular drug
Indication Edema associated with congestive heart failure [ICD9: 428.0, 782.3; ICD10:I50, R60.9] Approved [468068], [538352], [551871]
Therapeutic Class
Antihypertensive Agents
Company
Oak Pharmaceuticals Inc Sub Akorn Inc
Structure
Download
2D MOL

3D MOL
Formula
C7H6ClN3O4S2
InChI
InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
InChIKey
JBMKAUGHUNFTOL-UHFFFAOYSA-N
CAS Number
CAS 58-94-6
PubChem Compound ID
2720
PubChem Substance ID
9664, 542598, 855976, 4970936, 5051008, 7847585, 7978922, 8149249, 10321157, 10528492, 11110950, 11110951, 11335850, 11361089, 11363008, 11365570, 11368132, 11371323, 11373919, 11376294, 11462061, 11466279, 11467399, 11484024, 11486017, 11487970, 11490158, 11492095, 11493948, 15023005, 17389544, 17404817, 22425567, 24278150, 24714733, 26611653, 26680067, 26747285, 26747286, 29221877, 46507032, 47291140, 47291141, 47291142, 47515323, 47515324, 47662287, 47885422, 47959750, 48415760
SuperDrug ATC ID
C03AA04
SuperDrug CAS ID
cas=000058935
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [534975]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 468068(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4835).
Ref 538352FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 084026.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534975Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.

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