Drug Information

Drug General Information
Drug ID
D0MI1N
Former ID
DIB005238
Drug Name
CR-5259
Synonyms
CR-4144 series; CR-4152 series; CR-4153 series; CR-4167 series; Aggrecanase (ADAMTS-4 and 5) inhibitors (osteoarthritis),Rottapharm Madaus
Indication Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47] Investigative [543457]
Company
Rottapharm Madaus
Target and Pathway
Target(s) Aggrecanase Target Info Inhibitor [543457]
Reactome Degradation of the extracellular matrix
O-glycosylation of TSR domain-containing proteins
WikiPathways Endochondral Ossification
Vitamin D Receptor Pathway
References
Ref 543457(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1677).
Ref 543457(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1677).

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