| Drug General Information |
| Drug ID |
D0MJ3C
|
| Former ID |
DNC000719
|
| Drug Name |
GW9578
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C26H34F2N2O3S
|
| InChI |
InChI=1S/C26H34F2N2O3S/c1-4-5-6-7-8-16-30(25(33)29-23-14-11-20(27)18-22(23)28)17-15-19-9-12-21(13-10-19)34-26(2,3)24(31)32/h9-14,18H,4-8,15-17H2,1-3H3,(H,29,33)(H,31,32)
|
| InChIKey |
KYQNYMXQHLMADB-UHFFFAOYSA-N
|
| CAS Number |
CAS 247923-29-1
|
| PubChem Compound ID |
|
| PubChem Substance ID |
14835304, 22395210, 24161207, 45292565, 57373615, 58097987, 76940347, 103187316, 112379000, 125335700, 128453681, 134341499, 135362737, 135650342, 137038616, 139534992, 163122779, 198953743, 204371564, 226449107
|
| Target and Pathway |
| Target(s) |
Peroxisome proliferator activated receptor alpha |
Target Info |
Agonist |
[2]
|
|---|
|
KEGG Pathway
|
PPAR signaling pathway
|
|
cAMP signaling pathway
|
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Adipocytokine signaling pathway
|
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Glucagon signaling pathway
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
|
Hepatitis C
|
|
Pathway Interaction Database
|
RXR and RAR heterodimerization with other nuclear receptor
|
|
Reactome
|
RORA activates gene expression
|
|
BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
|
PPARA activates gene expression
|
|
YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
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Transcriptional activation of mitochondrial biogenesis
|
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Activation of gene expression by SREBF (SREBP)
|
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Transcriptional regulation of white adipocyte differentiation
|
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Nuclear Receptor transcription pathway
|
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Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
Circadian Clock
|
|
WikiPathways
|
Nuclear Receptors in Lipid Metabolism and Toxicity
|
|
Nuclear Receptors Meta-Pathway
|
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Estrogen Receptor Pathway
|
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PPAR Alpha Pathway
|
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Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
Transcriptional Regulation of White Adipocyte Differentiation
|
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YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
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Activation of Gene Expression by SREBP (SREBF)
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Adipogenesis
|
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SREBF and miR33 in cholesterol and lipid homeostasis
|
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Circadian Clock
|
|
Nuclear Receptors
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2673). |
|---|
| REF 2 | Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42. |
|---|
