Drug General Information
Drug ID	D0ML0L
Former ID	DNCL003495
Drug Name	ARRY-614
Drug Type	Small molecular drug
Indication	Arthritis; Myelodysplastic syndrome [ICD9: 710-719, 238.7; ICD10:M00-M25, D46]		Discontinued in Phase 1	[548520]
Company	Array BioPharma
Structure		Download 2D MOL 3D MOL
Formula	C31H33FN6O3
PubChem Compound ID	24765037
Target and Pathway
Target(s)	p38 mitogen-activated protein kinases	Target Info	Modulator
	Angiopoietin 1 receptor	Target Info	Modulator
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	HIF-1 signaling pathway
	PI3K-Akt signaling pathway
	Rheumatoid arthritis
NetPath Pathway	Wnt Signaling Pathway
PANTHER Pathway	Angiogenesis
Pathway Interaction Database	Angiopoietin receptor Tie2-mediated signaling
	SHP2 signaling
Reactome	Tie2 Signaling
	RAF/MAP kinase cascade
WikiPathways	Wnt Signaling Pathway Netpath
	Cell surface interactions at the vascular wall
	Angiogenesis
References
Ref 548520	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026289)

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