Drug General Information
Drug ID
D0MM4X
Former ID
DIB009807
Drug Name
MIV-710
Synonyms
MIV-711; MIV-711); Cathepsin K inhibitor (oral, osteoporosis), Medivir
Indication Bone metastases [ICD9: 198.5; ICD10:C79.51] Investigative [543600]
Company
Medivir AB
Structure
Download
2D MOL

3D MOL

Canonical SMILES
O=S(=O)(O[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(cc2)c2csc(N3<br />CCN(CC3)C)n2)CC(C)C)[C@H]2[C@@H]1OCC2=O)C
Target and Pathway
Target(s) Cathepsin K Target Info Modulator [543600]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 543600(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350).
Ref 543600(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.