Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0MM4X
|
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| Former ID |
DIB009807
|
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| Drug Name |
MIV-710
|
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| Synonyms |
MIV-711; MIV-711); Cathepsin K inhibitor (oral, osteoporosis), Medivir
|
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| Indication | Bone metastases [ICD9: 198.5; ICD10:C79.51] | Investigative | [1] | ||
| Company |
Medivir AB
|
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
O=S(=O)(O[C@@H]1CN(C(=O)[C@@H](NC(=O)c2ccc(cc2)c2csc(N3<br />CCN(CC3)C)n2)CC(C)C)[C@H]2[C@@H]1OCC2=O)C
|
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| Target and Pathway | |||||
| Target(s) | Cathepsin K | Target Info | Modulator | [1] | |
| KEGG Pathway | Lysosome | ||||
| Osteoclast differentiation | |||||
| Toll-like receptor signaling pathway | |||||
| Rheumatoid arthritis | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| RANKL Signaling Pathway | |||||
| IL2 Signaling Pathway | |||||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Trafficking and processing of endosomal TLR | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | RANKL/RANK Signaling Pathway | ||||
| Osteoclast Signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350). | ||||
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