Drug Information

Drug General Information
Drug ID
D0MS3D
Former ID
DIB019714
Drug Name
Delta12-PGJ2
Synonyms
Dddd-PGD2; delta(12)-PGJ2; delta-12-prostaglandin D2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539176]
Structure
Download
2D MOL
Formula
C20H30O4
InChI
InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/b7-4-,18-14+/t16-,17-/m0/s1
InChIKey
TUXFWOHFPFBNEJ-GJGHEGAFSA-N
PubChem Compound ID
5280885
PubChem Substance ID
8242, 4265964, 7979702, 8616424, 14717669, 14924517, 26754836, 26754837, 39289874, 47290909, 48334229, 50065349, 50110797, 57357910, 74919478, 85788020, 92309700, 99300614, 99302132, 103640340, 104046455, 113854167, 126525046, 135069677, 135081387, 135651467, 139340649, 179151368, 184568146, 229391737, 241151930, 252455424, 252467260, 252819674
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Agonist [526477]
Prostaglandin D2 receptor Target Info Agonist [534620]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Small Ligand GPCRs
GPCR downstream signaling
References
Ref 539176(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1876).
Ref 526477Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72.
Ref 534620Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.