Drug Information

Drug General Information
Drug ID
D0MT5C
Former ID
DPR000065
Drug Name
L-742791
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Preclinical [536122], [540405]
Company
Merck
Structure
Download
2D MOL

3D MOL
Formula
C23H25IN2O5S
InChI
InChI=1S/C23H25IN2O5S/c24-18-3-11-23(12-4-18)32(29,30)26-19-5-1-17(2-6-19)13-14-25-15-21(28)16-31-22-9-7-20(27)8-10-22/h1-12,21,25-28H,13-16H2/t21-/m0/s1
InChIKey
ZNTDIRUBXSTBGJ-NRFANRHFSA-N
PubChem Compound ID
16118894
PubChem Substance ID
24766058, 28721944, 40653259, 103174254, 103964070, 129929183, 178100461, 226633000
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [536122]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536122Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
Ref 540405(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3467).
Ref 536122Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.

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