TTD | Drug: D0N0IQ

Drug General Information
Drug ID	D0N0IQ
Former ID	DPR000100
Drug Name	Ro-27-3225
Drug Type	Small molecular drug
Indication	Obesity [ICD9: 278; ICD10:E66]		Preclinical	[536122]
Company	Roche; Millenium
Structure		Download 2D MOL 3D MOL
Formula	C41H54N10O6
Canonical SMILES	CCCC(=O)NC(CC1=CC=CC1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN<br />=C(N)N)C(=O)NC(CC3=C4C=CC=CC4=NC3)C(=O)N(C)CC(=O)N
InChI	1S/C41H54N10O6/c1-3-12-36(53)47-32(21-27-15-7-8-16-27)38(55)49-33(22-26-13-5-4-6-14-26)39(56)48-31(19-11-20-45-41(43)44)37(54)50-34(40(57)51(2)25-35(42)52)23-28-24-46-30-18-10-9-17-29(28)30/h4-10,13-15,17-18,31-34H,3,11-12,16,19-25H2,1-2H3,(H2,42,52)(H,47,53)(H,48,56)(H,49,55)(H,50,54)(H4,43,44,45)/t31-,32-,33?,34?/m0/s1
InChIKey	IRCWGIYPMAYZQR-URRMOVRVSA-N
PubChem Compound ID	56603736
PubChem Substance ID	134339540
Target and Pathway
Target(s)	Melanocortin-4 receptor	Target Info	Agonist	[536122]
KEGG Pathway	Neuroactive ligand-receptor interaction
Pathway Interaction Database	Syndecan-3-mediated signaling events
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (s) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 536122	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
Ref 536122	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.

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Drug Information