Drug Information

Drug General Information
Drug ID
D0N0IT
Former ID
DNC001575
Drug Name
CJ 11,974-01
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [537538]
Therapeutic Class
Analgesics
Structure
Download
2D MOL

3D MOL
Formula
C31H38N2O
Canonical SMILES
CC(C)C1=CC(=C(C=C1)OC)CNC2C3CCN(C2C(C4=CC=CC=C4)C5=CC=C<br />C=C5)CC3
InChI
1S/C31H38N2O/c1-22(2)26-14-15-28(34-3)27(20-26)21-32-30-25-16-18-33(19-17-25)31(30)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-15,20,22,25,29-32H,16-19,21H2,1-3H3/t30-,31-/m0/s1
InChIKey
XPNMCDYOYIKVGB-CONSDPRKSA-N
PubChem Compound ID
188927
PubChem Substance ID
14833513, 14931234, 16943245, 33510538, 50151433, 57396200, 103066084, 103080324, 103623465, 104111218, 113444847, 117534974, 129722546, 134340704, 135165523, 135958003, 142437557, 178102377, 179680024, 198946391, 226713777, 234513239
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [537538]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 537538Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice. Life Sci. 2009 Aug 12;85(7-8):309-15.
Ref 537538Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice. Life Sci. 2009 Aug 12;85(7-8):309-15.

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