TTD | Drug: D0N1AS

Drug General Information
Drug ID	D0N1AS
Former ID	DCL000177
Drug Name	NGD-4715
Drug Type	Small molecular drug
Indication	Obesity [ICD9: 278; ICD10:E66]		Discontinued in Phase 1	[548402]
Company	Neurogen Corp
Structure		Download 2D MOL 3D MOL
Formula	C19H24BrN3O3
Canonical SMILES	COC1=C(C=C(C=C1)CN2CCN(CC2)C3=NC(=C(C=C3)Br)OC)OC
InChI	1S/C19H24BrN3O3/c1-24-16-6-4-14(12-17(16)25-2)13-22-8-10-23(11-9-22)18-7-5-15(20)19(21-18)26-3/h4-7,12H,8-11,13H2,1-3H3
InChIKey	VAKYVNYLCIABRV-UHFFFAOYSA-N
PubChem Compound ID	9866893
PubChem Substance ID	14831711, 24158595, 45289159, 49684274, 78707013, 134338852, 137142844, 142874149, 162222892, 223933055, 230614704, 249147908, 252215906
Target and Pathway
Target(s)	Melanin-concentrating hormone receptor 1	Target Info	Antagonist	[550543]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548402	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025311)
Ref 550543	CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.

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Drug Information