Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N1BC
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| Former ID |
DNC001206
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| Drug Name |
Reveromycin A
|
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Terminated | [545391] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C36H52O11
|
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| Canonical SMILES |
CCCCC1(CCC2(CCC(C(O2)CC=C(C)C=CC(C(C)C=CC(=O)O)O)C)OC1C<br />=CC(=CC(=O)O)C)OC(=O)CCC(=O)O
|
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| InChI |
1S/C36H52O11/c1-6-7-19-35(47-34(44)17-16-32(40)41)21-22-36(46-30(35)14-10-25(3)23-33(42)43)20-18-27(5)29(45-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12,14-15,23,26-30,37H,6-7,13,16-22H2,1-5H3,(H,38,39)(H,40,41)(H,42,43)/b12-8+,14-10+,15-11+,24-9+,25-23+/t26-,27-,28-,29+,30-,35?,36-/m0/s1
|
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| InChIKey |
ZESGNAJSBDILTB-BUCOAGSWSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | Isoleucyl-tRNA synthetase (bacterial) | Target Info | Inhibitor | [535471], [535599] | |
| Isoleucyl-tRNA synthetase, cytoplasmic (human) | Target Info | Inhibitor | [536729] | ||
| BioCyc Pathway | TRNA charging | ||||
| KEGG Pathway | Aminoacyl-tRNA biosynthesis | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| WikiPathways | tRNA Aminoacylation | ||||
| References | |||||
| Ref 535471 | Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. J Biol Chem. 2002 Aug 9;277(32):28810-4. Epub 2002 Jun 5. | ||||
| Ref 535599 | Chemical modification of reveromycin A and its biological activities. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3363-6. | ||||
| Ref 536729 | Synthesis and biological activities of reveromycin A and spirofungin A derivatives. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3756-60. Epub 2008 May 17. | ||||
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