Drug Information

Drug General Information
Drug ID
D0N2CN
Former ID
DNC011679
Drug Name
GR-175737
Drug Type
Small molecular drug
Indication Discovery agent Terminated [538757], [546329]
Structure
Download
2D MOL

3D MOL
Formula
C14H13ClN4O
InChI
InChI=1S/C14H13ClN4O/c15-11-3-1-10(2-4-11)7-13-18-14(20-19-13)6-5-12-8-16-9-17-12/h1-4,8-9H,5-7H2,(H,16,17)
InChIKey
CPOUJACQGWJJQB-UHFFFAOYSA-N
PubChem Compound ID
9838905
PubChem Substance ID
14800004, 14849081, 44936993, 77360480, 85221662, 103177095, 103964124, 134348884, 135650315, 226553737
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [534790]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538757(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1243).
Ref 546329Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007507)
Ref 534790Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8.New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine.

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