Drug Information

Drug General Information
Drug ID
D0N2GC
Former ID
DIB007877
Drug Name
BMS-753493
Synonyms
Epofolate; Epothilone folate conjugate; BMS-493; BMS-748285 folate conjugate, Bristol-Myers Squibb; Targeted epothilone-folate conjugate (Endocyte technology, cancer), BMS; Targeted epothilone-folate conjugate (Endocyte technology, cancer), Bristol-Myers Squibb
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1/2 [522150], [539707]
Company
Bristol-Myers Squibb Co
Structure
Download
2D MOL

3D MOL
Formula
C29H24O2
InChI
InChI=1S/C29H24O2/c1-29(2)19-18-24(14-10-21-6-4-3-5-7-21)26-20-23(13-17-27(26)29)9-8-22-11-15-25(16-12-22)28(30)31/h3-9,11-13,15-18,20H,19H2,1-2H3,(H,30,31)/b9-8+
InChIKey
YCADIXLLWMXYKW-CMDGGOBGSA-N
CAS Number
CAS 958646-17-8
PubChem Compound ID
9909190
PubChem Substance ID
14879386, 24190014, 45980852, 79025542, 93578140, 103587015, 135650003, 143057107, 162247366, 194945736, 204378860, 229684142, 229684147, 241376483, 249617892, 252157315
Target and Pathway
Target(s) Folate receptor alpha Target Info Modulator [533020]
KEGG Pathway Endocytosis
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
Cargo concentration in the ER
WikiPathways Folate Metabolism
References
Ref 522150ClinicalTrials.gov (NCT00550017) A Phase 1/2 Study of Epofolate (BMS-753493) in Subjects With Advanced Cancer (Schedule 2). U.S. National Institutes of Health.
Ref 539707(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2641).
Ref 533020A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):321-31.

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