TTD | Drug: D0N3OH

Drug General Information
Drug ID	D0N3OH
Former ID	DNC002332
Drug Name	A-317920
Drug Type	Small molecular drug
Indication	Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90]		Investigative	[538727]
Company	Abbott
Structure		Download 2D MOL 3D MOL
Formula	C25H31N3O5
InChI	InChI=1S/C25H31N3O5/c1-18(26-24(30)22-4-2-16-33-22)25(31)28-14-12-27(13-15-28)11-3-17-32-21-9-7-20(8-10-21)23(29)19-5-6-19/h2,4,7-10,16,18-19H,3,5-6,11-15,17H2,1H3,(H,26,30)/t18-/m1/s1
InChIKey	RTRADBQSZJIRMT-GOSISDBHSA-N
PubChem Compound ID	10389213
PubChem Substance ID	15404795, 22741056, 34108821, 79205284, 103442142, 104045280, 135319051, 135649872, 198940008, 232882014
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Antagonist	[536039]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538727	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1216).
Ref 536039	The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.

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Drug Information