Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N3TO
|
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| Former ID |
DIB002722
|
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| Drug Name |
TRM-115
|
||||
| Synonyms |
TRM-15
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Gastric ulcer [ICD9: 531; ICD10:K25] | Discontinued in Phase 1 | [1] | ||
| Company |
Terumo Corp
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H36N4O4S
|
||||
| Canonical SMILES |
C(=S)(Nc1cc2c(OCO2)cc1)NCCCC(=O)NCCCOc1cc(CN2CCCCC2)ccc<br />1
|
||||
| CAS Number |
CAS 147779-46-2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H2 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretion | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Histamine H2 receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
| Gastric Acid Production | |||||
| Reactome | Histamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002138) | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002138) | ||||
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