Drug Information

Drug General Information
Drug ID
D0N4EO
Former ID
DIB002179
Drug Name
GMI-1070
Synonyms
GMI-1010; GMI-1011; GMI-1040 series; GMI-1077; Glyosin, GlycoMimetics; Heterobifunctional glycomimetic pan-selectin inhibitors (smallmolecule therapeutic), GlycoMimetics; Selectin inhibitors (asthma/sickle cell anemia/hematological neoplasm), GlycoMimetics
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 3 [530945], [531721], [543059]
Company
Glycomimetics; pfizer
Structure
Download
2D MOL

3D MOL
Formula
C58H74N6O31S3
InChI
InChI=1S/C58H74N6O31S3/c1-27-45(69)47(71)48(72)56(90-27)95-49-35(62-53(74)36-23-41(66)64-58(78)63-36)19-31(20-37(49)92-57-51(94-55(77)29-10-6-3-7-11-29)50(46(70)39(24-65)93-57)91-38(54(75)76)16-28-8-4-2-5-9-28)52(73)60-13-12-59-42(67)25-88-14-15-89-26-43(68)61-34-21-32(96(79,80)81)17-30-18-33(97(82,83)84)22-40(44(30)34)98(85,86)87/h3,6-7,10-11,17-18,21-23,27-28,31,35,37-39,45-51,56-57,65,69-72H,2,4-5,8-9,12-16,19-20,24-26H2,1H3,(H,59,67)(H,60,73)(H,61,68)(H,62,74)(H,75,76)(H,79,80,81)(H,82,83,84)(H,85,86,87)(H2,63,64,66,78)/t27-,31+,35-,37+,38-,39+,45+,46-,47+,48-,49+,50-,51+,56-,57+/m0/s1
InChIKey
VXBNTHRZPJLRSS-PTCSXESPSA-N
PubChem Compound ID
44232546
PubChem Substance ID
163716232, 172232580, 198970850, 252166519
Target and Pathway
Target(s) E-selectin Target Info Inhibitor [530945], [531721], [544142]
L-selectin Target Info Inhibitor [530945], [531721], [544142]
P-selectin Target Info Inhibitor [530945], [531721], [544142]
KEGG Pathway Cell adhesion molecules (CAMs)
TNF signaling pathway
African trypanosomiasis
Malariahsa04514:Cell adhesion molecules (CAMs)hsa04514:Cell adhesion molecules (CAMs)
Malaria
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
ID Signaling PathwayNetPath_20:IL9 Signaling Pathway
IL2 Signaling Pathway
Leptin Signaling Pathway
Pathway Interaction Database Thromboxane A2 receptor signaling
Glucocorticoid receptor regulatory network
ATF-2 transcription factor networkil4_2pathway:IL4-mediated signaling events
amb2 Integrin signaling
Reactome Cell surface interactions at the vascular wallR-HSA-198933:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wallR-HSA-114608:Platelet degranulation
Cell surface interactions at the vascular wall
WikiPathways Human Complement System
TNF alpha Signaling Pathway
Cell surface interactions at the vascular wallWP2806:Human Complement System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Spinal Cord Injury
Cell surface interactions at the vascular wall
References
Ref 530945GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood. 2010 Sep 9;116(10):1779-86.
Ref 531721Deal watch: Pfizer deal for selectin inhibitor highlights potential of glycomimetic drugs. Nat Rev Drug Discov. 2011 Dec 1;10(12):890.
Ref 543059(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8307).
Ref 530945GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood. 2010 Sep 9;116(10):1779-86.
Ref 531721Deal watch: Pfizer deal for selectin inhibitor highlights potential of glycomimetic drugs. Nat Rev Drug Discov. 2011 Dec 1;10(12):890.
Ref 544142GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood. 2010 September 9; 116(10): 1779-1786.

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