Drug Information

Drug General Information
Drug ID
D0N4JI
Former ID
DIB006045
Drug Name
APG-101
Synonyms
CD95 receptor extracellular domain-IgG fused protein (GvHD), Apogenix; CD95 receptor extracellular domain-IgG fused protein (myocardial infarction), Apogenix; CD95 receptor extracellular domain-IgG fused protein (stroke), Apogenix; CD95 receptor extracellular domain-immunoglobulin G fused protein (graft versus hostdisease), Apogenix
Indication Cerebrovascular ischaemia [ICD9: 434.91; ICD10:I61-I63] Phase 2 [522954]
Company
Apogenix GmbH
Target and Pathway
Target(s) CD95 Target Info Inhibitor [531855]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
p53 signaling pathway
Apoptosis
Natural killer cell mediated cytotoxicity
TNF signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Type I diabetes mellitus
Alzheimer's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Hepatitis B
Measles
Influenza A
Herpes simplex infection
Pathways in cancer
Proteoglycans in cancer
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host disease
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
FAS signaling pathway
p53 pathway
Pathway Interaction Database p73 transcription factor network
FAS (CD95) signaling pathway
Direct p53 effectors
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Validated transcriptional targets of TAp63 isoforms
Reactome FasL/ CD95L signaling
WikiPathways DNA Damage Response
TCR Signaling Pathway
Apoptosis Modulation by HSP70
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Apoptosis
Integrated Pancreatic Cancer Pathway
Adipogenesis
Allograft Rejection
Alzheimers Disease
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
miRNA Regulation of DNA Damage Response
References
Ref 522954ClinicalTrials.gov (NCT01071837) APG101 in Glioblastoma. U.S. National Institutes of Health.
Ref 531855Pharmacokinetics, pharmacodynamics, safety and tolerability of APG101, a CD95-Fc fusion protein, in healthy volunteers and two glioma patients. Int Immunopharmacol. 2012 May;13(1):93-100.

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