Drug Information

Drug General Information
Drug ID
D0N4WB
Former ID
DNC004415
Drug Name
SB-415286
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542926]
Structure
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2D MOL

3D MOL
Formula
C16H10ClN3O5
InChI
InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
InChIKey
PQCXVIPXISBFPN-UHFFFAOYSA-N
PubChem Compound ID
4210951
PubChem Substance ID
6173380, 8387211, 11109050, 11111800, 11114154, 11121581, 11122061, 11362650, 11365212, 11367774, 11370571, 11370572, 11373375, 11375936, 14828233, 17405044, 24278412, 26752224, 35496324, 47498109, 47498110, 47719265, 48317018, 49674511, 50069834, 50104914, 50104915, 53777587, 53789039, 56463775, 57356843, 71745855, 78669802, 85231226, 85788271, 90341705, 91722320, 92303814, 92309932, 99300846, 99302364, 103336904, 104022026, 112770517, 121264554, 121361147, 124659173, 124801122, 124881441, 124881442
Target and Pathway
Target(s) Glycogen synthase kinase-3 beta Target Info Inhibitor [529753]
Ribosomal protein S6 kinase Target Info Inhibitor [526012]
KEGG Pathway ErbB signaling pathway
Chemokine signaling pathway
Cell cycle
PI3K-Akt signaling pathway
Wnt signaling pathway
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
T cell receptor signaling pathway
B cell receptor signaling pathway
Neurotrophin signaling pathway
Dopaminergic synapse
Insulin signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Hepatitis C
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Endometrial cancer
Prostate cancer
Basal cell carcinomahsa04012:ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
AMPK signaling pathway
TGF-beta signaling pathway
Fc gamma R-mediated phagocytosis
Proteoglycans in cancer
Acute myeloid leukemia
Choline metabolism in cancer
PANTHER Pathway Alzheimer disease-presenilin pathway
Angiogenesis
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PDGF signaling pathway
PI3 kinase pathway
Wnt signaling pathway
Ras Pathway
CCKR signaling map STP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
p53 pathway by glucose deprivation
CCKR signaling map ST
Pathway Interaction Database LPA receptor mediated events
Degradation of beta catenin
Reelin signaling pathway
Presenilin action in Notch and Wnt signaling
Integrin-linked kinase signaling
CDC42 signaling events
LKB1 signaling events
Canonical Wnt signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
C-MYC pathway
Regulation of Androgen receptor activity
BMP receptor signaling
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by Stem cell factor receptor (c-Kit)
Validated transcriptional targets of deltaNp63 isoforms
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
p53 pathway
Trk receptor signaling mediated by PI3K and PLC-gammainsulin_pathway:Insulin Pathway
IL4-mediated signaling events
Angiopoietin receptor Tie2-mediated signaling
Regulation of Telomerase
mTOR signaling pathway
IGF1 pathway
IL2 signaling events mediated by PI3K
Integrins in angiogenesis
RXR and RAR heterodimerization with other nuclear receptor
a6b1 and a6b4 Integrin signaling
TGF-beta receptor signaling
PathWhiz Pathway Leucine Stimulation on Insulin Signaling
Reactome Degradation of beta-catenin by the destruction complex
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in CancerR-HSA-166208:mTORC1-mediated signalling
WikiPathways DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Notch Signaling Pathway
Glycogen Metabolism
Insulin Signaling
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
IL-6 signaling pathway
Wnt Signaling Pathway Netpath
Copper homeostasis
Focal Adhesion
Hair Follicle Development: Induction (Part 1 of 3)
Cardiac Hypertrophic Response
Degradation of beta-catenin by the destruction complex
T-Cell Receptor and Co-stimulatory Signaling
Cardiac Progenitor Differentiation
BDNF signaling pathway
Corticotropin-releasing hormone
B Cell Receptor Signaling Pathway
IL17 signaling pathway
Neural Crest Differentiation
Alzheimers Disease
IL-7 Signaling Pathway
Regulation of Microtubule Cytoskeleton
TWEAK Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Cell Cycle
MicroRNAs in cardiomyocyte hypertrophy
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP673:ErbB Signaling Pathway
Interferon type I signaling pathways
G13 Signaling Pathway
IL-2 Signaling Pathway
Cytoplasmic Ribosomal Proteins
EGF/EGFR Signaling Pathway
IL-4 Signaling Pathway
Kit receptor signaling pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Interleukin-11 Signaling Pathway
FSH signaling pathway
TSH signaling pathway
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
IL-5 Signaling Pathway
References
Ref 542926(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8019).
Ref 526012Bioorg Med Chem Lett. 2001 Mar 12;11(5):635-9.3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).
Ref 529753Eur J Med Chem. 2009 Jun;44(6):2361-71. Epub 2008 Sep 16.Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models.

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