Drug Information

Drug General Information
Drug ID
D0N5AY
Former ID
DIB007829
Drug Name
Ranagengliotucel-T
Synonyms
Glionix; Brain tumor vaccine, NovaRx; Antisense (TGFbeta) brain tumor vaccine, NovaRx
Drug Type
Vaccine
Indication Brain cancer [ICD9: 191, 225.0; ICD10:C71, D33] Discontinued in Phase 3 [547548]
Company
NovaRx Corp
Target and Pathway
Target(s) mRNA of TGF beta-2 ligand Target Info [547547]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Cell cycle
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
HTLV-I infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Chronic myeloid leukemia
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy
NetPath Pathway TCR Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway TGF-beta signaling pathway
Pathway Interaction Database Glypican 1 network
ATF-2 transcription factor network
Signaling events mediated by the Hedgehog family
Regulation of retinoblastoma protein
TGF-beta receptor signaling
Reactome Platelet degranulation
Molecules associated with elastic fibres
ECM proteoglycans
WikiPathways Endochondral Ossification
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
NRF2 pathway
Extracellular vesicle-mediated signaling in recipient cells
Extracellular matrix organization
Elastic fibre formation
References
Ref 547548Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017210)
Ref 547547Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017210)

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