Drug Information

Drug General Information
Drug ID
D0N5SC
Former ID
DCL000661
Drug Name
UK-369003
Drug Type
Small molecular drug
Indication Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] Discontinued in Phase 1/2 [541682], [547526]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C23H33N7O5S
InChI
InChI=1S/C23H33N7O5S/c1-5-18-19-20(27-30(18)12-13-34-4)22(31)26-21(25-19)17-14-16(15-24-23(17)35-7-3)36(32,33)29-10-8-28(6-2)9-11-29/h14-15H,5-13H2,1-4H3,(H,25,26,31)
InChIKey
YPFZMBHKIVDSNR-UHFFFAOYSA-N
PubChem Compound ID
9892860
PubChem Substance ID
14860624, 45639794, 80803364, 124490361, 134339182, 135262720, 136920538, 136963794, 137053215, 142091546, 162514236, 178103172, 198945523, 223668068, 223889841, 226492532, 244141555
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [525340], [549974]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 541682(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6558).
Ref 547526Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017097)
Ref 525340ClinicalTrials.gov (NCT00457457) Pfizer. Report of Pfizer. September 2 2008.
Ref 549974Pfizer. Product Development Pipeline. March 31 2009.

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