TTD | Drug: D0N5SS

Drug General Information
Drug ID	D0N5SS
Former ID	DCL000453
Drug Name	AZD1175
Indication	Hypertension; Diabetes; Obesity [ICD9: 250, 278, 401; ICD10:E08-E13, E66, I10-I16]		Discontinued in Phase 1	[548277]
Company	AstraZeneca
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Cannabinoid receptor 1	Target Info	Antagonist	[550288]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
PANTHER Pathway	Endogenous cannabinoid signaling
Pathway Interaction Database	N-cadherin signaling events
Reactome	Class A/1 (Rhodopsin-like receptors)
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 548277	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024090)
Ref 550288	Clinical pipeline report, company report or official report of AstraZeneca (2009).

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Drug Information