Drug Information

Drug General Information
Drug ID
D0N6EB
Former ID
DIB001134
Drug Name
CG-0070
Synonyms
CG-5757; Oncolytic virus therapy, Cell Genesys; Oncolytic virus therapy, Cold Genesys
Indication Bladder cancer [ICD9: 188; ICD10:C67] Discontinued in Phase 2/3 [547793]
Company
Cold genesys
Target and Pathway
Target(s) Granulocyte-macrophage colony-stimulating factor Target Info Agonist [550905]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Salmonella infection
Amoebiasis
HTLV-I infection
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
TNFalpha Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
Alpha9 beta1 integrin signaling events
AP-1 transcription factor network
Calcium signaling in the CD4+ TCR pathway
Syndecan-2-mediated signaling events
Regulation of retinoblastoma protein
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways Cytokines and Inflammatory Response
Hematopoietic Stem Cell Differentiation
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 547793Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019332)
Ref 550905US patent application no. 2012,0082,687, Use of cell adhesion inhibitor for the mobilization of antigen presenting cells and immune cells in a cell mixture (aim) from the peripheral blood and methodsof use.

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