TTD | Drug: D0N6IG

Drug General Information
Drug ID	D0N6IG
Former ID	DIB002307
Drug Name	H3 receptor inverse agonists
Synonyms	H3 receptor inverse agonists (CNS disorders, obesity); H3 receptor inverse agonists(CNS disorders, obesity), Roche
Indication	Central nervous system disease [ICD10:G00-G99]		Investigative	[552077]
Company	F Hoffmann-La Roche Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(c1n(c2c(c1)cc(cc2)OC1CCN(CC1)C(C)C)C(C)C)N1CCC(CC<br />1)(F)F
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Agonist	[543673]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 552077	Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5713-7
Ref 543673	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264).

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Drug Information