Drug Information

Drug General Information
Drug ID
D0N6KO
Former ID
DIB004563
Drug Name
THIQ
Synonyms
THIQ; MB-243; MC4 receptor agonists (obesity); MK-0489; MZ-767; PG-917; PG-946; RY-764; Anti-obesity therapy, Merck &Co; MC4 receptor agonists (obesity), Merck & Co; Melanocortin agonists (obesity/erectile dysfunction), Merck & Co
Drug Type
Small molecular drug
Indication Erectile dysfunction [ICD9: 302.72, 607.84; ICD10:F52.2, N48.4] Investigative [538817]
Company
Merck & Co Inc
Structure
Download
2D MOL

3D MOL
Formula
C33H41ClN6O2
InChI
InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1
InChIKey
HLCHESOMJVGDSJ-LOYHVIPDSA-N
PubChem Compound ID
9938402
PubChem Substance ID
14911585, 14963853, 24211890, 50076885, 76478875, 103354844, 104012586, 135262322, 135651261, 141973091, 172917585, 228084613, 241376224, 247273883, 249617741, 252156960
Target and Pathway
Target(s) Melanocortin-4 receptor Target Info Agonist [543735]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Syndecan-3-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538817(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1338).
Ref 543735(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 285).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.