Drug Information

Drug General Information
Drug ID
D0N6TR
Former ID
DAP000638
Drug Name
Sulfadoxine
Synonyms
Fanasil; Fanzil; Orthosulfin; Solfadossina; Sulfadoxin; Sulfadoxina; Sulfadoxinum; Sulformethoxine; Sulformetoxine; Sulforthomidine; Sulphadoxine; Sulphormethoxine; Sulphormetoxin; Sulphorthodimethoxine; Solfadossina [DCIT]; WR 4073; WR 4873; Ro 4-4393; Sulfadoxina [INN-Spanish]; Sulfadoxinum [INN-Latin]; Ro-4-4393; Sanasil: Sulfadoxine: Sulformetoxin; Sulfadoxine (JAN/USP/INN); Sulfadoxine [USAN:INN:BAN:JAN]; N1-(5,6-Dimethoxy-4-pyrimidinyl)sulfanilamide; N'-(5,6-Dimethoxy-4-pyrimidyl)sulfanilamide; N(sup 1)-(5,6-Dimethoxy-4-pyrimidinyl)sulfanilamide; 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide; 4-Sulfanilamido-5,6-dimethoxypyrimidine; 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide; 4-amino-N-[5,6-bis(methyloxy)pyrimidin-4-yl]benzenesulfonamide; 6-(4-Aminobenzenesulfonamido)-4,5-dimethoxypyrimidine
Drug Type
Small molecular drug
Indication Malaria [ICD10:B54] Approved [538509]
Therapeutic Class
Antimalarials
Structure
Download
2D MOL

3D MOL
Formula
C12H14N4O4S
Canonical SMILES
COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N
InChI
1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
InChIKey
PJSFRIWCGOHTNF-UHFFFAOYSA-N
CAS Number
CAS 2447-57-6
PubChem Compound ID
17134
PubChem Substance ID
9832, 602990, 7728975, 7847646, 7980700, 8162831, 11112518, 11467122, 11468242, 11486790, 14776546, 24870487, 24899765, 29284909, 46507915, 47574681, 47796319, 47871029, 47945128, 48416567, 49699291, 49881199, 50100470, 50139239, 50761334, 56313708, 56463175, 57329659, 85788593, 87244217, 92126034, 92308171, 92309303, 92711246, 103567590, 103914678, 104253663, 104341678, 117487474, 119525732, 121363705, 124757846, 124766495, 124799375, 125164650, 125311902, 125345920, 126631055, 126657468, 126664632
ChEBI ID
ChEBI:9329
Target and Pathway
Target(s) Dihydropteroate synthetase Target Info Inhibitor [536658]
References
Ref 538509FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018557.
Ref 536658Geographical distribution of amino acid mutations in Plasmodium vivax DHFR and DHPS from malaria endemic areas of Thailand. Am J Trop Med Hyg. 2008 Mar;78(3):462-7.

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