Drug Information

Drug General Information
Drug ID
D0NC1D
Former ID
DIB000468
Drug Name
MX-6120
Synonyms
MX-6120; Endothelin-1 antagonists (heart disease); ET-1 antagonists (heart disease), Maxia; Endothelin-1 antagonists (heart disease), Maxia
Indication Heart disease [ICD9: 390-429; ICD10:I00-I52] Terminated [547652]
Company
Maxia Pharmaceuticals Inc
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Antagonist [527075]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547652Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018158)
Ref 527075Endothelin receptor antagonists in heart failure: current status and future directions. Drugs. 2004;64(10):1029-40.

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