TTD | Drug: D0NJ7Y

Drug General Information
Drug ID	D0NJ7Y
Former ID	DIB019908
Drug Name	GlaxoSmithKline compound 5h
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530970], [541127]
Structure		Download 2D MOL
Formula	C29H32N2O2
InChI	InChI=1S/C29H32N2O2/c1-4-5-6-10-21-15-17-23(18-16-21)30-29(32)31-26-14-9-11-22-19-27(33-28(22)26)25-13-8-7-12-24(25)20(2)3/h7-9,11-20H,4-6,10H2,1-3H3,(H2,30,31,32)
InChIKey	ASCJIAKBYVUVNZ-UHFFFAOYSA-N
PubChem Compound ID	46911435
PubChem Substance ID	99372430, 103765879, 104143115, 178102432
Target and Pathway
Target(s)	P2Y purinoceptor 1	Target Info	Antagonist	[530970]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	G alpha (q) signalling events
	P2Y receptors
	ADP signalling through P2Y purinoceptor 1
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 530970	Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4104-7.
Ref 541127	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5807).
Ref 530970	Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4104-7.

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Drug Information