Drug Information

Drug General Information
Drug ID
D0NQ0B
Former ID
DIB021239
Drug Name
XNT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529403], [542795]
Structure
Download
2D MOL
Formula
C25H26N2O6S
InChI
InChI=1S/C25H26N2O6S/c1-16-4-8-19(9-5-16)34(30,31)33-18-7-11-22-20(14-18)24(29)23-21(26-12-13-27(2)3)10-6-17(15-28)25(23)32-22/h4-11,14,26,28H,12-13,15H2,1-3H3
InChIKey
SEVKFSGZVZFIMA-UHFFFAOYSA-N
PubChem Compound ID
337294
PubChem Substance ID
464300, 604738, 4410545, 37528295, 49755074, 78246846, 104540570, 125704871, 129225951, 135245043, 162924994, 176224745, 184534479, 215779885, 223366197, 223563356, 228658428
Target and Pathway
Target(s) Recombinant human angiotensin converting enzyme 2 Target Info Activator [529403]
KEGG Pathway Renin-angiotensin system
Protein digestion and absorption
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 529403Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension. 2008 May;51(5):1312-7.
Ref 542795(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7867).
Ref 529403Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension. 2008 May;51(5):1312-7.

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