Drug Information

Drug General Information
Drug ID
D0O1YH
Former ID
DNC007258
Drug Name
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole
Synonyms
4,5,6,7-tetrabromobenzotriazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527308]
Structure
Download
2D MOL

3D MOL
Formula
C6HBr4N3
Canonical SMILES
C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br
InChI
1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
InChIKey
OMZYUVOATZSGJY-UHFFFAOYSA-N
PubChem Compound ID
1694
Target and Pathway
Target(s) Mitogen-activated protein kinase 14 Target Info Inhibitor [527308]
Mitogen-activated protein kinase 11 Target Info Inhibitor [527308]
Dual specificity mitogen-activated protein kinase kinase 1 Target Info Inhibitor [527308]
Lck tyrosine kinase Target Info Inhibitor [527308]
RAC serine/threonine-protein kinase Target Info Inhibitor [527308]
Protein kinase C, alpha type Target Info Inhibitor [527308]
Mitogen-activated protein kinase 8 Target Info Inhibitor [527308]
Glycogen synthase kinase-3 beta Target Info Inhibitor [527308]
MAP kinase p38 Target Info Inhibitor [527308]
Rho-associated protein kinase 1 Target Info Inhibitor [527308]
Ribosomal protein S6 kinase Target Info Inhibitor [527308]
Serine/threonine-protein kinase Chk1 Target Info Inhibitor [527308]
AMP-activated protein kinase Target Info Inhibitor [527308]
Serine/threonine-protein kinase Sgk1 Target Info Inhibitor [527308]
Mitogen-activated protein kinase 1 Target Info Inhibitor [527308]
Casein kinase II, alpha chain Target Info Inhibitor [530101]
KEGG Pathway MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
Epstein-Barr virus infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
Oocyte meiosis
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
Dorso-ventral axis formation
Focal adhesion
Gap junction
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Long-term potentiation
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Alcoholism
Hepatitis B
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04064:NF-kappa B signaling pathway
HTLV-I infection
Primary immunodeficiencyhsa04010:MAPK signaling pathway
mTOR signaling pathway
AMPK signaling pathway
Apoptosis
Tight junction
Jak-STAT signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Non-alcoholic fatty liver disease (NAFLD)
Carbohydrate digestion and absorption
Measles
Small cell lung cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Calcium signaling pathway
Phosphatidylinositol signaling system
Wnt signaling pathway
Circadian entrainment
Glutamatergic synapse
GABAergic synapse
Insulin secretion
Thyroid hormone synthesis
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Pathogenic Escherichia coli infection
African trypanosomiasis
Amoebiasis
Protein processing in endoplasmic reticulum
Type II diabetes mellitus
Herpes simplex infection
Choline metabolism in cancerhsa04012:ErbB signaling pathway
Cell cycle
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
Alzheimer's disease
Basal cell carcinomahsa04010:MAPK signaling pathway
Proteoglycans in cancerhsa04022:cGMP-PKG signaling pathway
TGF-beta signaling pathway
MicroRNAs in cancerhsa04012:ErbB signaling pathway
Choline metabolism in cancerhsa04110:Cell cycle
p53 signaling pathway
Viral carcinogenesishsa04068:FoxO signaling pathway
Regulation of autophagy
Circadian rhythm
Hypertrophic cardiomyopathy (HCM)hsa04068:FoxO signaling pathway
Aldosterone-regulated sodium reabsorptionhsa04010:MAPK signaling pathway
Adherens junction
Viral carcinogenesis
Choline metabolism in cancerhsa03008:Ribosome biogenesis in eukaryotes
NF-kappa B signaling pathway
NetPath Pathway IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_25:FSH Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling PathwayNetPath_23:TSH Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
TNFalpha Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_25:FSH Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Angiogenesis
B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Interferon-gamma signaling pathway
Oxidative stress response
Parkinson disease
TGF-beta signaling pathway
Toll receptor signaling pathway
VEGF signaling pathway
Ras Pathway
p53 pathway feedback loops 2
p38 MAPK pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
p38 MAPK pathwayP00005:Angiogenesis
Endothelin signaling pathway
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Integrin signalling pathway
PDGF signaling pathway
T cell activation
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00049:Parkinson disease
T cell activationP00005:Angiogenesis
Apoptosis signaling pathway
Huntington disease
Hypoxia response via HIF activation
Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PI3 kinase pathway
p53 pathway
p53 pathway by glucose deprivation
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
FAS signaling pathway
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
p38 MAPK pathwayP00016:Cytoskeletal regulation by Rho GTPase
CCKR signaling map STP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
CCKR signaling map ST
Pathway Interaction Database Endothelins
BCR signaling pathway
p73 transcription factor network
p38 MAPK signaling pathway
Atypical NF-kappaB pathway
IL4-mediated signaling events
CD40/CD40L signaling
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
CDC42 signaling events
Angiopoietin receptor Tie2-mediated signaling
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
Rapid glucocorticoid signaling
Regulation of Androgen receptor activity
ATF-2 transcription factor network
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
Retinoic acid receptors-mediated signaling
CXCR3-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
EPO signaling pathway
Signaling events mediated by VEGFR1 and VEGFR2
p53 pathway
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
VEGFR3 signaling in lymphatic endothelium
FGF signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
Plasma membrane estrogen receptor signaling
Regulation of retinoblastoma proteinfcer1pathway:Fc-epsilon receptor I signaling in mast cells
GMCSF-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
EPHB forward signaling
SHP2 signaling
Netrin-mediated signaling events
mTOR signaling pathway
Class IB PI3K non-lipid kinase events
Ras signaling in the CD4+ TCR pathway
Ceramide signaling pathway
IFN-gamma pathway
ErbB1 downstream signaling
ErbB2/ErbB3 signaling events
FOXM1 transcription factor network
PDGFR-beta signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Nongenotropic Androgen signaling
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cellular roles of Anthrax toxin
Downstream signaling in na&#xef
Signaling events mediated by focal adhesion kinasenfkappabatypicalpathway:Atypical NF-kappaB pathway
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
TCR signaling in na&#xef
CXCR4-mediated signaling events
Class I PI3K signaling events
IL2 signaling events mediated by PI3K
amb2 Integrin signaling
EPHA forward signaling
IL2 signaling events mediated by STAT5
Ephrin B reverse signaling
Alpha-synuclein signalingsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Fc-epsilon receptor I signaling in mast cells
LPA receptor mediated events
Insulin Pathway
S1P3 pathway
Coregulation of Androgen receptor activity
Reelin signaling pathway
Integrin-linked kinase signaling
Regulation of Telomerase
FOXA2 and FOXA3 transcription factor networks
IGF1 pathway
FoxO family signaling
p75(NTR)-mediated signaling
E-cadherin signaling in the nascent adherens junction
Integrins in angiogenesis
E-cadherin signaling in keratinocytes
Nephrin/Neph1 signaling in the kidney podocyte
IL8- and CXCR2-mediated signaling events
Signaling events mediated by the Hedgehog family
Caspase Cascade in Apoptosis
VEGFR1 specific signals
a6b1 and a6b4 Integrin signaling
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
IL8- and CXCR1-mediated signaling events
HIF-1-alpha transcription factor network
Trk receptor signaling mediated by PI3K and PLC-gamma
FGF signaling pathwayendothelinpathway:Endothelins
Canonical NF-kappaB pathway
Signaling events regulated by Ret tyrosine kinase
Syndecan-4-mediated signaling events
PAR1-mediated thrombin signaling events
Regulation of Ras family activation
Fc-epsilon receptor I signaling in mast cells
RhoA signaling pathway
Noncanonical Wnt signaling pathway
Osteopontin-mediated events
TRAIL signaling pathway
IL1-mediated signaling events
JNK signaling in the CD4+ TCR pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Syndecan-2-mediated signaling events
N-cadherin signaling events
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4lysophospholipid_pathway:LPA receptor mediated events
Degradation of beta catenin
Presenilin action in Notch and Wnt signaling
LKB1 signaling events
Canonical Wnt signaling pathway
C-MYC pathway
BMP receptor signaling
Validated transcriptional targets of deltaNp63 isoforms
Trk receptor signaling mediated by PI3K and PLC-gammarhoa_pathway:RhoA signaling pathway
Signaling mediated by p38-gamma and p38-deltaprlsignalingeventspathway:Signaling events mediated by PRL
PAR4-mediated thrombin signaling events
Stabilization and expansion of the E-cadherin adherens junction
N-cadherin signaling eventsinsulin_pathway:Insulin Pathway
RXR and RAR heterodimerization with other nuclear receptor
TGF-beta receptor signalingfanconi_pathway:Fanconi anemia pathway
ATR signaling pathway
Circadian rhythm pathway
p53 pathwayinsulin_pathway:Insulin Pathway
Class I PI3K signaling eventsfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Signaling events mediated by PRL
ErbB4 signaling events
S1P4 pathway
S1P1 pathway
Arf6 downstream pathway
EGF receptor (ErbB1) signaling pathway
ALK1 signaling events
Syndecan-1-mediated signaling events
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Alpha-synuclein signaling
Signaling events mediated by focal adhesion kinasebcr_5pathway:BCR signaling pathway
DNA-PK pathway in nonhomologous end joining
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-alpha signaling pathway
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Insulin SignallingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Insulin Signalling
Leucine Stimulation on Insulin SignalingPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptorPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Fc Epsilon Receptor I Signaling in Mast CellsPW000659:Leucine Stimulation on Insulin SignalingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-110056:MAPK3 (ERK1) activation
Uptake and function of anthrax toxins
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activationR-HSA-114604:GPVI-mediated activation cascade
PIP3 activates AKT signaling
Regulation of KIT signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
Interleukin-2 signalingR-HSA-111447:Activation of BAD and translocation to mitochondria
GPVI-mediated activation cascade
Translocation of GLUT4 to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin alphaIIb beta3 signaling
Deactivation of the beta-catenin transactivating complex
G beta:gamma signalling through PI3Kgamma
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in CancerR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+R-HSA-193648:NRAGE signals death through JNK
NRIF signals cell death from the nucleus
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-195253:Degradation of beta-catenin by the destruction complex
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in CancerR-HSA-168638:NOD1/2 Signaling Pathway
VEGFA-VEGFR2 PathwayR-HSA-111465:Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases Activate ROCKsR-HSA-166208:mTORC1-mediated signallingR-HSA-176187:Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-1445148:Translocation of GLUT4 to the plasma membrane
Macroautophagy
TP53 Regulates Metabolic GenesR-HSA-2672351:Stimuli-sensing channelsR-HSA-112409:RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Golgi Cisternae Pericentriolar Stack Reorganization
Regulation of actin dynamics for phagocytic cup formation
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signalingR-HSA-2514853:Condensation of Prometaphase Chromosomes
WikiPathways Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Interferon type I signaling pathways
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
Oxidative Stress
p38 MAPK Signaling Pathway
IL-4 Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
Kit receptor signaling pathway
Cardiac Hypertrophic Response
MAP kinase activation in TLR cascade
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
JAK/STAT
Amyotrophic lateral sclerosis (ALS)
Alpha 6 Beta 4 signaling pathway
Cardiac Progenitor Differentiation
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Parkinsons Disease Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
B Cell Receptor Signaling Pathway
Prostate Cancer
TSLP Signaling Pathway
TWEAK Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
IL-1 signaling pathway
Signal amplification
Platelet homeostasis
NGF signalling via TRKA from the plasma membrane
Myogenesis
DSCAM interactions
MicroRNAs in cardiomyocyte hypertrophy
Angiogenesis
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Estrogen signaling pathway
ErbB Signaling Pathway
Hypothetical Network for Drug Addiction
EPO Receptor Signaling
Regulation of Actin Cytoskeleton
IL-2 Signaling Pathway
IL-6 signaling pathway
Signaling of Hepatocyte Growth Factor Receptor
Focal Adhesion
IL-3 Signaling Pathway
Bladder Cancer
RAF/MAP kinase cascade
Genes and (Common) Pathways Underlying Drug Addiction
Nifedipine Activity
Aryl Hydrocarbon Receptor
PDGF Pathway
Interleukin-11 Signaling Pathway
Signaling Pathways in Glioblastoma
IL-9 Signaling Pathway
Endothelin Pathways
IL-7 Signaling Pathway
TSH signaling pathway
Signaling by FGFR
Integrin-mediated Cell Adhesion
L1CAM interactions
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
IL-5 Signaling PathwayWP61:Notch Signaling Pathway
Inflammatory Response Pathway
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
TCR signaling
Costimulation by the CD28 familyWP75:Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
Notch Signaling Pathway
Endochondral Ossification
Wnt Signaling Pathway Netpath
Copper homeostasis
Extracellular vesicle-mediated signaling in recipient cells
Apoptosis-related network due to altered Notch3 in ovarian cancer
Translocation of GLUT4 to the Plasma Membrane
Signal Transduction of S1P Receptor
Primary Focal Segmental Glomerulosclerosis FSGS
Apoptosis
TNF alpha Signaling Pathway
IL17 signaling pathway
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
SREBP signalling
Integrated Cancer pathway
Metabolism of nitric oxide
TFs Regulate miRNAs related to cardiac hypertrophy
TOR Signaling
AMPK Signaling
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP673:ErbB Signaling Pathway
Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Transcriptional activation by NRF2
Myometrial Relaxation and Contraction Pathways
Human Complement System
Syndecan interactions
DAG and IP3 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Pathogenic Escherichia coli infection
miRs in Muscle Cell Differentiation
Opioid Signalling
Response to elevated platelet cytosolic Ca2+
Integration of energy metabolism
TOR SignalingWP75:Toll-like receptor signaling pathway
FAS pathway and Stress induction of HSP regulation
NLR Proteins
EBV LMP1 signaling
Nanoparticle triggered regulated necrosis
Signalling by NGF
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
Type II diabetes mellitus
Osteoclast SignalingWP710:DNA Damage Response (only ATM dependent)
Glycogen Metabolism
Hair Follicle Development: Induction (Part 1 of 3)
Degradation of beta-catenin by the destruction complex
Neural Crest Differentiation
Alzheimers Disease
Semaphorin interactions
Cell Cycle
IL-5 Signaling PathwayWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathwayWP524:G13 Signaling Pathway
GPCR downstream signaling
Apoptotic execution phase
Androgen receptor signaling pathwayWP673:ErbB Signaling Pathway
G13 Signaling Pathway
Cytoplasmic Ribosomal Proteins
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by Insulin receptor
IL-5 Signaling PathwayWP707:DNA Damage Response
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP481:Insulin Signaling
Energy dependent regulation of mTOR by LKB1-AMPK
SREBF and miR33 in cholesterol and lipid homeostasis
AMPK SignalingWP481:Insulin Signaling
Iron uptake and transport
FSH signaling pathwayWP75:Toll-like receptor signaling pathway
Vitamin A and Carotenoid Metabolism
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Thrombin signalling through proteinase activated receptors (PARs)
Advanced glycosylation endproduct receptor signaling
Heart Development
IL-5 Signaling PathwayWP2652:Mitotic Prometaphase
References
Ref 527308J Med Chem. 2004 Dec 2;47(25):6239-47.Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Ref 527308J Med Chem. 2004 Dec 2;47(25):6239-47.Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Ref 530101Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. Epub 2009 Apr 22.Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.

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